成年人骨质疏松症相关体质指数的临界值研究

A threshold study of osteoporosis (OP) related body mass index (BMI) in adults

目的 探讨新疆居民体质指数(BMI)与骨质疏松症(OP)的关系,寻找降低骨质疏松症风险的BMI临界值,为骨质疏松症的预防提供科学依据。方法 基于“新疆多民族自然人群队列建设及健康随访研究”基线调查数据,骨密度(BMD)T分数作为评定骨质疏松症的标准。采用多因素Logistic回归模型分析BMI与OP的相关性,并使用限制性立方样条(RCS)探讨BMI与OP患病风险的关系,找出骨质疏松症风险的BMI临界值。结果 本研究共纳入13 804名具有完整数据的参与者,其中有812名(14.33%)男性骨质疏松症患者和1 386名(17.04%)女性骨质疏松症患者。单因素分析结果显示两组在年龄、社会经济地位、体力活动类型、是否患有高血压、骨折史方面具有统计学差异(P<0.05);BMI与骨质疏松症患病相关,且与骨质疏松症的风险呈非线性关系(P<0.01),男性、绝经前女性、绝经后女性RCS图中临界BMI值分别为24.47 kg/m^(2)、24.79 kg/m^(2)、27.37 kg/m^(2)。结论 BMI与骨质疏松症的发病风险呈非线性关系,且不同性别和绝经状态下的个体在BMI值与骨质疏松症患病风险之间存在不同的临界点,这为不同人群利用BMI值预防骨质疏松症提供了一定的参考。

Objective To explore the relationship between body mass index(BMI) and osteoporosis(OP) in Xinjiang residents,to find the critical value of BMI to reduce the risk of OP,and to provide a scientific basis for OP prevention.Methods Based on the baseline survey data of the Xinjiang Multi-ethnic Natural Population Cohort Construction and Health Follow-up Study,bone mineral density(BMD) T-score was used as criterion for assessing OP.A multifactorial Logistic regression model was used to analyze the correlation between BMI and OP,and restricted cubic spline(RCS) was used to explore the relationship between BMI and the risk of developing OP,and to find out the critical value of BMI for OP.Results A total of 13 804 participants with complete data were included in this study,including 812(14.33%) men with osteoporosis and 1 386(17.04%) women with OP.The results of univariate analysis showed statistically significant differences between the 2 groups in terms of age,socioeconomic status,type of physical labor,having hypertension and history of fracture(P<0.05);BMI was associated with the prevalence of OP and had a nonlinear relationship with the risk of OP(P<0.01),and the critical BMI values in the RCS plots of males,pre-menopausal females and post-menopausal females were 24.47 kg/m~2,24.79 kg/m~2,and 27.37 kg/m~2.Conclusion BMI has a nonlinear relationship with the risk of osteoporosis,and there are different critical points between BMI values and the risk of osteoporosis in individuals of different genders and menopausal states,which provides a certain reference for the prevention of osteoporosis in different populations by utilizing BMI values.