中医理论视域下创新中药发现策略和实践

Strategies and Practices for Discovery of Innovative Traditional Chinese Medicine from the Perspective of Traditional Chinese Medicine Theory

在现代科学技术飞速发展的新形势下,源于中医临床的中药创新药物发现在应对新发疾病、重大疾病具有鲜明的中医药特色和优势,探索合理的创新中药发现策略、研究路径是我国中医药创新发展的关键问题。中医药具有完整独特的理论体系和丰富的临床实践积累,在中医理论指导下,临床驱动、主动创新、中西医结合,是我国具有中医药特色的药物发现的重要途径。本文就中医理论指导下的中药创新药物发现研究思路进行阐述,列举了近年来基于中药的药物发现研究成果和相关新兴研究策略,为现代中药创新药物研发提供一定的思路和参考。

Under the new situation of rapid development of modern science and technology,innovative drug discovery originating from Traditional Chinese Medicine(TCM)clinical practice has distinct characteristics and advantages in responding to new and major diseases.Exploring reasonable research strategies and paths is a key issue for the innovative development of TCM.Chinese medicine has built a unique theoretical system and accumulated rich clinical practice.Under the guidance of Chinese medicine theory,based on clinical experience,active innovation,combination of Chinese and Western medicine.This is an important way for the discovery of drugs with TCM characteristics.This article elaborates on the discovery ideas of innovative TCM under the guidance of traditional Chinese medicine theory,and lists the research achievements and related emerging research strategies in recent years,providing certain ideas and references for the research and discovery of innovative drugs originating from TCM.