参矾解毒方溻渍疗法促进包皮环切术后伤口愈合的临床观察

Clinical observation on the promotion of wound healing after circumcision using Shenfan-Jiedu decoction in external medicinal liquid application

目的比较两种不同频次的参矾解毒方溻渍疗法治疗包皮环切术后伤口疼痛、愈合的临床疗效。方法运用回顾性队列研究设计,予108例包皮环切术后患者参矾解毒方溻渍外用于术后局部伤口,根据不同用药频率分为低剂量暴露组(每日1次)和高剂量暴露组(每日2次),每组各54例,均于术后第4天开始连续治疗7 d。随访用药前和用药7 d后术口疼痛程度;6周内患者的愈合情况、术后并发症。结果与低剂量暴露组相比,高剂量暴露组愈合时间较短(P<0.001),VAS评分较低(P<0.001)。两组患者未见相关术后并发症。结论基于清热燥湿、解毒消肿、活血生肌之功效的参矾解毒方溻渍疗法对包皮环切术后伤口有促进愈合、缓解疼痛的作用,且与用药频率呈正相关。

Objective To compare the clinical efficacy of two different frequency treatments of Shenfan-Jiedu decoction in external medicinal liquid application for wound healing and pain after circumcision.Method A retrospective cohort study design was used to divide 108 patients after circumcision into a low-dose exposure group(once a day)and a high-dose exposure group(twice a day)based on two different medication frequencies of Shenfan-Jiedu decoction.The patients in each group were treated with Shenfan-Jiedu decoction externally on the local wound after surgery,and treatment began continuously for 7 days on the 4th day after surgery.Patient's healing status,postoperative complications,and degree of intraoperative pain before and 7 days after medication within 6 weeks were followed up.Result Compared with the low-dose exposure group,the high-dose exposure group had a shorter healing time(P<0.001)and a lower VAS score(P<0.001).No postoperative complications were observed in the two groups.Conclusion Based on the effects of clearing heat and dampness,detoxifying and reducing swelling,and promoting blood circulation and generating muscle,the Shenfan-Jiedu decoction has an obvious promoting effect on wound healing and relieving pain after circumcision,and is positively correlated with medication frequency.