复方玄驹胶囊联合减压宁神方治疗心因性勃起功能障碍的多中心临床疗效观察

Clinical efficacy of compound Xuanju capsule combined with decompression and Ninxin formula in the treatment of cardiac erectile dysfunction

目的观察复方玄驹胶囊联合减压宁神方治疗心因性勃起功能障碍的临床疗效。方法通过互联网+随访模式展开临床疗效观察,将按标准纳入的患者分成三组:玄驹组(复方玄驹胶囊,3粒/次,tid)、减压组(减压宁神方,1袋,bid)以及玄驹+减压联合组(上述两药同剂量联合用药)。治疗周期为4周,分别收集治疗前和治疗后的国际勃起功能评分(IIEF-5)、勃起硬度评估表(EHS)、伯恩斯抑郁症清单(BDC)、汉密尔顿抑郁量表(HAMD-17项)等。通过治疗前后对比和组间差异对比,分析各组疗效情况。结果治疗前,两组患者的IIEF-5评分、EHS评分、BDC评分、HAMD-17项评分均无显著性差异(P>0.05),治疗4周后三组中IIFE-5、EHS指标均高于治疗前(P<0.05),BDC、HAMD-17项指标均低于治疗前(P<0.05)。在改善值方面,玄驹+减压联合组治疗后各项参数的改善值均显著高于玄驹组和减压组。治疗后联合组睾酮(T)水平高于玄驹组和减压组,雌二醇(E_(2))水平低于玄驹组和减压组(P<0.05)。结论复方玄驹胶囊联合减压宁神方可显著提高心因性勃起功能障碍患者的勃起功能评分,降低心理学量表评分,临床治疗安全有效。

The First Affiliated Hospital of Zhengzhou University;Shandong Provincial Hospital;Shengjing Hospital of China Medical University;Sichuan Provincial People's Hospital;Xiangya Hospital of Central South University;Shiqiang Digital Intelligence Health Industry Group Co.,Ltd.,Department of Medicine;Objective To observe the clinical efficacy of compound XuanJu capsule combined with decompression NingXin formula in the treatment of psychogenic erectile dysfunction.Methods Clinical efficacy observation was carried out through the Internet+follow-up mode,and the patients included according to the criteria were divided into three groups,Xuanju group(compound Xuanju capsule,3 capsules/times,tid),decompression group(decompression NingXin formula,1 sachet,bid),and the combination group of Xuanju+decompression(the above two medicines were used at the same dosage).The treatment cycle was 1 month,and the International Erectile Function Score(IIEF-5),Erectile Hardness Scale(EHS),Burns Depression Checklist(BDC),and Hamilton Depression Inventory(HAMD-17 items)were collected before and after treatment,respectively.The efficacy of each group was analyzed by comparing before and after treatment and comparing the differences between groups.Results Before treatment,there was no significant difference in the IIEF-5 score,EHS score,BDC score,and HAMD-17 item score between the two groups(P>0.05).After one month of treatment,IIFE-5 and EHS indexes were higher than before treatment in all three groups(P<0.05),and BDC and HAMD-17 item indexes were lower than before treatment(P<0.05).In terms of improvement values,the improvement values of all parameters after treatment in the combined Xuanju+decompression group were significantly higher than those in the Xuanju and Decompression groups.The T level in the combined group after treatment was higher than that in the Xuanju and decompression groups,and the E_(2) level was lower than that in the compound Xuanju and decompression groups(P<0.05).Conclusion Compound Xuanju capsule combined with decompression NingXin formula can significantly improve the erectile function scores of patients with psychological cardiac erectile dysfunction and reduce the psychological scale scores,which is safe and effective in clinical treatment.