肌钙蛋白I水平升高与脑梗死患者早期转归的关系研究

A Study on the Relationship between Elevated Troponin I and Early Outcome of Cerebral Infarction Patients

目的分析脑梗死患者早期转归与肌钙蛋白I(cTnI)水平升高的相关性。方法收集2023年1月-12月医院收治的75例脑梗死患者为研究对象,根据治疗后14 d改良Rankin评分将患者分为转归组(n=48)与未转归组(n=27)。记录两组年龄、性别、合并症等一般资料,比较C反应蛋白(CRP)、同型半胱氨酸(Hcy)、D-二聚体(D-D)、cTnI升高比例,分析cTnI与CRP、Hcy、D-D的相关性,并对患者早期转归影响因素进行Logistic回归分析。结果转归组患者CRP、Hcy、D-D、cTnI水平低于未转归组,cTnI升高占比低于未转归组,差异有统计学意义(P<0.05)。cTnI水平与CRP、Hcy、D-D水平呈现正相关(P<0.05);Logistic分析发现,CRP、Hcy、D-D水平、cTnI升高与脑梗死早期转归独立相关。结论cTnI升高与脑梗死患者早期转归密切相关,监测cTnI水平可预测患者预后,从而为临床治疗提供参考。

Objective:To Objective To analyze the correlation between the early prognosis of patients with cerebral infarction and the increase of troponin I(cTnI).Methods:Seventy-five patients with cerebral infarction admitted to the hospital from January to December,2023 were selected as the research objects.According to the modified Rankin score 14 days after treatment,the patients were divided into the prognosis group(n=48)and the nonprognosis group(n=27).The general data of age,sex and complications of the two groups were recorded,and the rising ratios of C-reactive protein(CRP),homocysteine(Hcy),D-dimer(D-D)and cTnI were compared.The correlation between cTnI and CRP、Hcy and D-D was analyzed,and the influencing factors of patients'early prognosis were analyzed by Logistic regression.Results:The levels of CRP、Hcy、D-D、cTnI in patients with prognosis group were lower than those in patients without prognosis group,and the proportion of elevated cTnI was lower than that in patients without prognosis group,with statistical significance(P<0.05).The level of cTnI was positively correlated with CRP,Hcy and D-D(P<0.05).Logistic analysis showed that the increase of CRP、Hcy、DD and cTnI were independently related to the early prognosis of cerebral infarction.Conclusion:The increase of cTnI is closely related to the early prognosis of patients with cerebral infarction.Monitoring the level of cTnI can predict the prognosis of patients,thus providing reference for clinical treatment.