组织p53、EGFR与炎症因子水平在肺癌术后感染中的变化及意义

Changes and significance of tissue p53,EGFR and inflammatory factors in postoperative infection of lung cancer

目的 探讨组织p53、表皮生长因子受体(EGFR)与炎症因子水平在肺癌术后感染中的变化及意义,为今后临床预防术后感染提供思路。方法 选择2020年2月-2022年9月于霍山县医院治疗的肺癌患者80例进行研究,所有患者均给予手术治疗。根据术后感染发生情况将其分为感染组(n=21)和未感染组(n=59)。比较两组组织p53、EGFR阳性率、炎症因子[降钙素原(PCT)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平;分析组织p53、EGFR与炎症因子水平变化情况及其之间的相关性。结果 感染组患者组织p53、EGFR阳性率(42.86%、57.14%)均显著高于未感染组(18.64%、5.08%),差异均有统计学意义(χ^(2)=4.843、27.551,P均<0.05)。感染组PCT、IL-6、CRP水平分别为(0.47±0.12) ng/mL、(85.33±22.05) pg/mL、(115.17±26.41) mg/mL,均显著高于未感染组[(0.25±0.06) ng/mL、(13.24±2.75) pg/mL、(28.69±4.12)mg/mL],差异均有统计学意义(t=10.849、24.855、24.596,P均<0.05)。多因素非条件logistic分析显示,p53、EGFR、PCT、IL-6及CRP水平升高均是肺癌术后感染的独立危险因素,差异均有统计学意义(P均<0.05)。相关性分析结果显示,p53、EGFR与PCT、IL-6、CRP之间均成正相关(r=0.511、0.423、0.468,0.495、0.408、0.515,P均<0.05)。结论 肺癌术后感染患者中p53、EGFR与炎症因子水平均呈上升趋势,可能是肺癌术后感染的危险因素。

Objective To study the changes and significance of tissue p53, epidermal growth factor receptor(EGFR) and inflammatory factors in postoperative infection of lung cancer, to provide ideas for future clinical prevention of postoperative infection. Methods A total of 80 patients with lung cancer treated in the Huoshan County Hospital from February 2020 to September 2022 were selected for the study, all received surgical treatment. According to the incidence of postoperative infection, the patients were divided into infected group(n=21) and uninfected group(n=59). The positive rates of p53, EGFR and the levels of procalcitonin(PCT), interleukin-6(IL-6) and C-reactive protein(CRP) in the two groups were compared. The changes of tissue p53, EGFR and inflammatory factors and their correlation were analyzed. Results The positive rates of p53 and EGFR in the infected group(42.86%, 57.14%) were significantly higher than those in the uninfected group(18.64%, 5.08%);the differences were statistically significant (χ^(2)=4.843, 27.551;both P<0.05). The levels of PCT, IL-6 and CRP in the infection group were(0.47±0.12)ng/mL,(85.33±22.05)pg/mL,(115.17±26.41)mg/mL,which were significantly higher than those in the uninfected group [(0.25±0.06)ng/mL,(13.24±2.75)pg/mL,(28.69±4.12)mg/mL];the differences were statistically significant(t=10.849, 24.855, 24.596;all P<0.05). Multivariate unconditional logistic analysis showed that the increased levels of p53, EGFR, PCT, IL-6 and CRP were independent risk factors for postoperative infection in patients with lung cancer;the differences were statistically significant(all P<0.05). Correlation analysis results showed that p53, EGFR were positively correlated with PCT, IL-6 and CRP(r=0.511, 0.423, 0.468;0.495, 0.408, 0.515;all P<0.05). Conclusion The levels of p53, EGFR and inflammatory factors were all increased in patients with postoperative infection of lung cancer, which might be the risk factors for postoperative infection of lung cancer.