哺乳动物雷帕霉素靶蛋白信号通路在糖尿病视网膜病变中作用的研究进展

Research progress of the m TOR signaling pathway in diabetic retinopathy

DR是DM微血管病变,是不可逆性失明的主要原因。随着DM人数增加,DR患病率升高,因治疗方法有限,整体治愈率低。哺乳动物雷帕霉素靶蛋白(m TOR)作为高血糖传感器,在DR的发生发展中起重要作用。本文综述m TOR信号通路在DR中作用的研究进展。

Diabetic retinopathy(DR) is a microvascular lesion in diabetes mellitus(DM),which is the main cause of irreversible blindness.The prevalence of DR increases as the number of DM patients increases.Due to limited treatment options,the overall cure rate is low.Mammalian target of rapamycin(m TOR) plays an important role in the occurrence and development of diabetic retinopathy as a hyperglycemic sensor.This article reviews the research progress on the role of mTOR signaling pathway in DR.