ABC转运蛋白在肿瘤多药耐药中的研究进展

Progress of Research on ABC Transporters in Tumor Multidrug Resistance

ABC转运蛋白是具有ATP酶活性并能够跨膜转运底物的膜蛋白超家族。其中,ABCB1、ABCG2、ABCC1与肿瘤多药耐药(MDR)密切相关,是ABC转运蛋白超家族中的研究重点和热点。本文旨在综述ABCB1、ABCG2、ABCC1转运蛋白在肿瘤多药耐药中的最新机制,并探讨靶向抑制这些转运蛋白的最新策略,以期为MDR机制研究及其逆转剂研发提供较系统的参考。

The ATP-binding cassette(ABC)transporter superfamily comprises membrane proteins that efflux various substrates across extra-and intracellular membranes.Among them,ABCB1,ABCG2,and ABCC1 are directly linked to tumor multidrug resistance(MDR).This review provides an overview of the current understanding on the novel mechanisms and functions of ABCB1,ABCG2,and ABCC1 transporters in tumor MDR,discusses the latest strategies to target these transporters,and explores further opportunities to overcome MDR.