摘要
长链非编码RNA(long non-coding RNA,lncRNA)之前被认为不能编码蛋白质,但目前越来越多的研究发现,lncRNA可以通过自身的小开放阅读框编码少于100个氨基酸的微肽(micro-peptide),已有研究报道这些微肽在癌症发生发展中发挥重要作用。为了更好地阐释lncRNA编码微肽在肿瘤进展过程中的功能、机制和潜在的应用,本文主要围绕肝癌中lncRNA及其翻译产生的微肽作一概述。
Long non-coding RNA(lncRNA)was previously thought to be unable to encode proteins,but more and more studies have found that lncRNA can encode micro-peptides of less than 100 amino acids through its own small open reading frame.Studies have reported that these micro-peptides play important roles in the occurrence and development of cancer.In order to better explain the function,mechanism and potential application of lncRNA-encoded micro-peptides in tumor progression,this article mainly provided an overview of lncRNA and the micro-peptides produced by lncRNA in liver cancer.
作者
苏泽文
郭明洲
骆健俊
SU Zewen;GUO Mingzhou;LUO Jianjun(Key Laboratory of Epigenetic Regulation and Intervention,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101;Department of Gastroenterology&Hepatology,the First Medical Center,Chinese PLA General Hospital,China)
出处
《胃肠病学和肝病学杂志》
CAS
2024年第7期808-810,共3页
Chinese Journal of Gastroenterology and Hepatology
基金
国家重点研发计划(2018YFA0208902,2020YFC2002705)
国家自然科学基金委员会资助项目(81672318,82272632)。
关键词
肝癌
长链非编码RNA
微肽
Liver cancer
Long non-coding RNA
Micro-peptide
