头孢哌酮舒巴坦联合甲泼尼龙琥珀酸钠治疗老年重症肺炎的效果观察

Observation on the Effect of Cefopcrazone Sulbactam Combined with Methylprednisolone Sodium Succinate in the Treatment of Severe Pneumonia in Elderly People

目的:观察头孢哌酮舒巴坦联合甲泼尼龙琥珀酸钠治疗老年重症肺炎的效果。方法:选取2018年6月—2022年6月临沂市莒南县人民医院收治的老年重症肺炎患者298例作为研究对象,随机分为对照组与观察组,各149例。两组均行常规治疗,对照组在常规治疗基础上联合甲泼尼龙琥珀酸钠治疗,观察组在对照组基础上联合头孢哌酮舒巴坦治疗。比较两组临床疗效,中性粒细胞/淋巴细胞(NLR)、单核细胞/淋巴细胞(MLR)和血小板/淋巴细胞(PLR)水平,不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.001)。治疗前,两组NLR、MLR、PLR水平比较,差异无统计学意义(P>0.05);治疗后,两组NLR、MLR、PLR水平降低,观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:头孢哌酮舒巴坦联合甲泼尼龙琥珀酸钠治疗老年重症肺炎的效果显著,可减轻炎性反应,改善免疫功能,且未增加不良反应发生率。

Objective:To observe the effect of cefopcrazone sulbactam combined with methylprednisolone sodium succinate in the treatment of severe pneumonia in the elderly.Methods:Two hundred and ninety-eight cases of elderly patients with severe pneumonia admitted to Linyi Junan County People's Hospital from June 2018 to June 2022 were selected as the study subjects,and randomly divided into the control group and the observation group,each with one hundred and forty-nine cases.Both groups underwent conventional treatment,the control group was treated with methylprednisolone sodium succinate on the basis of conventional treatment,and the observation group was treated with cefopcrazone sulbactam on the basis of the control group.The clinical efficacy,neutrophil/lymphocyte(NLR),monocyte/lymphocyte(MLR)and platelet/lymphocyte(PLR)levels,and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.001).Before treatment,the levels of NLR,MLR,and PLR were compared between the two groups,and the difference was not statistically significant(P>0.05);after treatment,the levels of NLR,MLR,and PLR were reduced in the two groups,and the level of NLR,MLR,and PLR in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Comparison of the total incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:Cefopcrazone sulbactam combined with methylprednisolone sodium succinate in the treatment of severe pneumonia in the elderly is effective,can reduce the inflammatory response,improve the immune function,and did not increase the incidence of adverse reactions.