不同糖耐量人群血清ANGPTL7水平与胰岛素抵抗的相关性

Correlation between serum ANGPTL7 level and insulin resistance in subjects with different glucose tolerance

目的 探讨不同糖耐量人群血清血管生成素样蛋白7(ANGPTL7)与胰岛素抵抗的关系。方法 选取2022年3-12月天津医科大学朱宪彝纪念医院就诊者和体检者159例。根据口服葡萄糖耐量试验(OGTT)结果将159例研究对象分为3组:糖耐量正常组(46例)、糖调节受损组(53例)、2型糖尿病(T2DM)组(60例)。检测所有研究对象血糖、糖化血红蛋白(HbAlc)、胰岛素、血脂、ANGPTL7和白细胞介素-1β(IL-1β)水平,计算胰岛素抵抗指数(HOMA-IR)。采用Pearson相关分析评估各项指标之间的相关性。结果 T2DM组ANGPTL7水平高于糖耐量正常组(P<0.05),而糖调节受损组与糖耐量正常组之间ANGPTL7水平差异无统计学意义(P>0.05)。T2DM组IL-1β水平均高于糖调节受损组和糖耐量正常组(P<0.05),糖调节受损组IL-1β水平高于糖耐量正常组(P<0.05)。T2DM组、糖调节受损组和糖耐量正常组之间空腹血糖(FPG)、空腹胰岛素(FINS)、2 h血糖(2 hPG)、HbAlc、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)差异均有统计学意义(P <0.001)。Pearson相关分析结果显示,ANGPTL7与FPG、FINS、2 hPG、HbAlc、TG、IL-1β、HOMA-IR均呈正相关(r值分别为0.316、0.225、0.359、0.296、0.197、0.202、0.260,P <0.05),与HDL-C呈负相关(r=-0.167,P <0.05)。结论 血清ANGPTL7水平随着胰岛素抵抗程度的加重而逐渐升高,ANGPTL7与T2DM的发生有一定关系。

Objective To investigate the relationship between serum angiopoietin-like protein 7(ANGPTL7)and insulin resistance in subjects with different glucose tolerance.Methods A total of 159 patients and healthy subjects from Chu Hsien-I Memorial Hospital of Tianjin Medical University from March 2022 to December 2022 were enrolled.According to oral glucose tolerance test(OGTT),159 subjects were classified into 3 groups,normal glucose tolerance group(46 cases),impaired glucose regulation group(53 cases)and type 2 diabetes mellitus(T2DM)group(60 cases).Blood glucose,glycated hemoglobin A1c(HbA1c),insulin,blood lipid,ANGPTL7 and interleukin-1 beta(IL-1β)levels were determined,and homeostasis model assessment of insulin resistance(HOMA-IR)was calculated.Pearson correlation analysis was used to evaluate the correlation among the indicators.Results The level of ANGPTL7 in T2DM group was higher than that in normal glucose tolerance group(P<0.05),but there was no statistical significance between impaired glucose regulation group and normal glucose tolerance group(P>0.05).The IL-1βlevel in T2DM group was higher than those in impaired glucose regulation group and normal glucose tolerance group(P<0.05),and the IL-1βlevel in impaired glucose regulation group was higher than that in normal glucose tolerance group(P<0.05).Fasting plasma glucose(FPG),fasting insulin(FINS),2 h postprandial blood glucose(2 hPG),HbA1c,triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)had statistical significance in T2DM group,impaired glucose regulation group and normal glucose tolerance group(P<0.001).ANGPTL7 was positively correlated with FPG,FINS,2 hPG,HbA_(lc),TG,IL-1βand HOMA-IR(r=0.316,0.225,0.359,0.296,0.197,0.202 and 0.260,respectively,P<0.05),and it was negatively correlated with HDL-C(r=-0.167,P<0.05).Conclusions Serum ANGPTL7 level increases gradually with the severity of insulin resistance,and ANGPTL7 is related to the occurrence of T2DM.