专利中药处方治疗放射性肺损伤的用药规律及作用机制研究

Medication pattern and mechanism of action of traditional Chinese medicine for the treatment of radiation-induced lung injury

目的:搜集国家专利中治疗放射性肺损伤的中药处方,探索其用药规律及作用机制。方法:检索国家知识产权局中国专利公布网站中治疗放射性肺损伤的中药处方,利用古今医案云平台进行统计分析、关联分析、聚类分析及网络构建分析等;通过网络药理学方法探讨治疗放射性肺损伤核心处方的作用靶点及相关通路。结果:纳入从专利数据库建立至2022年8月治疗放射性肺损伤的中药处方专利17项,共包含153味中药,药物出现频次较高的有甘草、生地黄;常用的药对为玄参-生地黄、苦杏仁-甘草、鱼腥草-甘草、生地黄-玄参;核心处方组成包括甘草、生地黄、苦杏仁、玄参和鱼腥草;核心处方治疗放射性肺损伤的主要靶点可能为JUN、IL-6、PTGS2、FOS、IL-8、IL-10等,相关的作用通路有脂质与动脉粥样硬化、化学致癌-受体激活、化学致癌-活性氧物种、PI3K-Akt信号通路、MAPK信号通路等。结论:专利中药处方主要可能通过抑制炎症反应从而发挥减轻放射性引起的肺损伤作用。

OBJECTIVE:To collect the patent prescriptions of traditional Chinese medicine for the treatment of radiation-induced lung injury,and to understand their mechanisms of action.METHODS:The Chinese patent publication website of the State Intellectual Property Office Traditional Chinese medicine prescriptions for the treatment of radiation-induced lung injury was reviewed to collect relevant information and the data were correlated,clustered and subjected to complex networks analysis using the ancient and modern medical record cloud platform.The action targets and related pathways of the core prescription were investigated via network pharmacology.RESULTS:From the establishment of the database since August 2022,17 patents of Chinese medicine prescriptions(with 153 medicines)for the prevention and treatment of radiation-induced lung injury were filed.The most commonly used medicine included liquorice(9 times,52.94%)and Radix Rehmanniae(5 times,29.41%).Mechanistically,these Chinese medicine have been described as cold in four Qi,sweet in five flavor,lung in meridian,and heat clearing and detoxification in efficacy.The commonly used drug pairs are Radix Scrophulariae rehmanniae,bitter almond licorice,Houttuynia licorice,Radix Rehmanniae Scrophulariae.The core prescription consisted of licorice,Rehmannia glutinosa,bitter almond,Radix Scrophulariae and Houttuynia cordata.The main targets of the core prescriptions might be JUN,IL-6,PTGS2,FOS,IL-8,IL-10,etc.and the relevant action pathways included lipid and atherosclerosis,chemical carcinogenesis receptor activation,chemical carcinogenesis reactive oxygen species,PI3K Akt signaling pathway,MAPK signaling pathway,etc.CONCLUSION:Our investigation indicates that the therapeutic mechanism for the patent prescription of Chinese medicine was by clearing away heat and detoxification,cooling blood,supplementing spleen and Qi,and evacuating wind heat.The mechanism of action may be through inhibiting inflammatory reaction,thus alleviating radiation-induced lung injury.