摘要
基于香豆素荧光团设计合成了一种光热剂(ECEI),其光热转换效率可达85.78%。此外,冷热循环的实验结果表明,ECEI具有良好的光稳定性。即使在线粒体膜电位受损的情况下,ECEI也能有效靶向线粒体,在激光照射下诱导癌细胞死亡。这使ECEI能够最大程度地破坏线粒体,从而抑制肿瘤细胞的繁殖。对小鼠肿瘤照射1次后,小鼠肿瘤在10 d内逐渐消失,这表明ECEI具有良好的肿瘤抑制效果。
A photothermal agent(ECEI)with high photothermal conversion efficiency(85.78%)was synthesized based on coumarin fluorescent groups.In addition,the experimental results of hot and cold cycling show that ECEI has good photostability.Despite damage to the mitochondrial membrane potential,ECEI can effectively target mitochondria and induce cancer cell death under laser irradiation.This allows ECEI to maximize mitochondrial damage and thus inhibit tumor cell reproduction.Notable,after irradiating mouse tumors once,the mouse tumors gradually disappeared within 10 d.This indicates that ECEI has an excellent tumor inhibition effect.
作者
刘涛
田钰婷
高珂
韩旭炜
闵薷楠
赵文静
孙学毅
阴彩霞
LIU Tao;TIAN Yuting;GAO Ke;HAN Xuwei;MIN Ru’nan;ZHAO Wenjing;SUN Xueyi;YIN Caixia(Department of Chemical and Material Engineering,Lyuliang University,Lüliang,Shanxi 033001,China;Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Institute of Molecular Science,Shanxi University,Taiyuan 030006,China;School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China)
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2024年第8期1622-1632,共11页
Chinese Journal of Inorganic Chemistry
基金
国家自然科学基金(No.22325703,22074084)
山西省应用基础研究面上基金(No.202203021221228)
山西省研究生教育教学改革课题(No.2022YJJG302)
吕梁市重点研发计划(高新技术领域)项目(No.2023GXYF04)资助。
关键词
光热疗法
肿瘤消融
高光热转换效率
photothermal therapy
tumor ablation
high photothermal conversion efficiency
