三叉神经射频消融术预防性使用抗菌药物的有效性、安全性及经济性评价

Efficacy,safety and economic evaluation of prophylactic antibiotics in patients with radiofrequency therapy of trigeminal neuralgia

目的通过对三叉神经射频消融术预防性使用抗菌药物的有效性、安全性及经济性进行评价,为临床合理用药提供参考。方法回顾性收集疼痛科2022年1至12月行三叉神经射频消融术的患者共51例,其中预防性使用抗菌药物31例为观察组,未预防性使用抗菌药物20例为对照组,比较2组的住院天数、有效率、不良事件发生率和感染发生率,并通过建立决策树模型进行经济学评价。结果2组住院天数、有效率及不良事件发生率比较差异均无统计学意义(P>0.05),2组均未发生术后感染情况。成本-效果分析发现三叉神经射频消融术未预防性使用抗菌药物为经济学优势方案。结论三叉神经射频消融术未预防性使用抗菌药物对临床结果无明显影响,并且可节省医疗成本。

AIM To evaluate the efficacy,safety and economy of prophylactic use of antibiotics in trigeminal nerve radiofrequency ablation,and to provide reference for clinical rational drug use.METHODS A total of 51 patients who underwent radiofrequency ablation of the trigeminal nerve in the department of pain medicine from January to December 2022 were retrospectively collected.Among them,31 patients were treated with prophylactic antibiotics as the observation group,and 20 patients were treated without prophylactic antibiotics as the control group.The hospitalization time,effective rate,incidence of adverse events and incidence of infection were compared between the 2 groups.The decision tree model was established for economic evaluation.RESULTS There was no significant difference in the length of hospital stay,effective rate and incidence of adverse events between 2 groups(P>0.05).There was no postoperative infection in 2 groups.According to the cost-effectiveness analysis,the non-prophylactic antibiotic therapy was an economically superior option.CONCLUSION Radiofrequency ablation of trigeminal neuralgia without prophylactic use of antibiotics has shown no significant effect on clinical results and could save medical costs.