国医大师林天东治疗Ⅲ型慢性前列腺炎用药规律

The Medication Patterns of National Chinese Medicine Master Lin Tiandong in the Treatment of Type II Chronic Prostatitis

目的:系统总结国医大师林天东教授治疗Ⅲ型慢性前列腺炎的用药规律及特点。方法:收集2022年3月至2023年6月海南省中医院国医大师林天东教授门诊收治的部分Ⅲ型慢性前列腺炎患者的处方,并对有效处方中高频药物的功效、药性、药味及归经等进行统计。使用Excel 2010软件建立原始数据库,使用SPSS 25.0软件进行描述性统计分析,通过Weka 3.8.6软件进行关联规律分析,并应用熵层次聚类法得出组合新方。最后利用Cytoscape 3.9.1软件将这些关联规则制作成可视化的网络视图。结果:共收集国医大师林天东教授治疗Ⅲ型慢性前列腺炎的有效处方206个,涉及46味中药,使用频次≥150次的中药有黄柏、车前子、茯苓、苦参、白茅根等。药物功效以清热燥湿药物居多,其次为利尿通淋类、利水消肿类和清热解毒类;药性以寒性多见,平性、温性次之;药味以苦味最为多见,其次为甘味、辛味、淡味;归经以肾经最为突出,其次为肝经、胃经、膀胱经。根据关联规则分析,黄柏-车前子是支持度最高的药对,其次是茯苓-黄柏、茯苓-车前子、苦参-黄柏、苦参-车前子等,并在此基础上进行熵层次聚类法分析得到5首新处方。结论:国医大师林天东教授治疗Ⅲ型慢性前列腺炎,以清热燥湿为治疗原则,辅以利尿通淋、泻火解毒、行滞散瘀等,所选用的药物多为寒性、平性、温性等,且以苦味、甘味、辛味、淡味药物多见。

Objective:To systematically summarize the medication patterns and characteristics of national Chinese medicine master Lin Tiandong in the treatment of typeⅢchronic prostatitis.Methods:The formulas of some patients with type II chronic prostatitis treated by Lin Tiandong,a national Chinese medicine master at Hainan Traditional Chinese Medicine Hospital from March 2022 to June 2023 were collected,and the efficacy,properties,taste,and meridian tropism of high-frequency drugs in effective formulas were statistically analyzed.The original database was established by using Excel 2010 software,and descriptive statistical analysis was conducted by using SPSS 25.0 software.By analyzing Weka 3.8.6 software,potential correlation patterns between formula drugs were discovered,and a new combination formula was obtained by applying entropy hierarchical clustering method.Finally,Cytoscape 3.9.1 software was used to create a visual WebView of these association rules.Results:A total of 206 effective formulas of national Chinese medicine master Lin Tiandong for the treatment of chronic prostatitis typeⅢwere collected,involving 46 kinds of Chinese medicinals.The drugs used more than 150 times included 14 kinds of Chinese medicinals such as Huangbai(Cortex Phellodendri Chinensis),Cheqianzi(Herba Plantaginis),Fuling(Poria),Kushen(Radix Sophorae Flavescentis),and Baimaogen(Rhizoma Imperatae),etc.The Analysis of drug efficacy was dominated by drugs that clear heat and dry dampness,followed by drugs that promote urination and clear urinary tract infections,diuretic and edema-relieving drugs,and drugs that clear heat and detoxify.The drug nature was mostly cold,followed by neutral and warm nature.The taste of the drug was mostly bitter,followed by sweet,pungent,and bland.The meridian tropism was mostly the kidney meridian,followed by the liver meridian,stomach meridian,and bladder meridian.According to association rule analysis,Huangbo-Cheqian was the most supported drug pair,followed by Fuling-Huangbai,Fuling-Cheqianzi,Kushen-Huangbai,Kushen-Cheqianzi,etc.Based on this,an entropy hierarchical clustering method was used to analyze the data,resulting in the discovery of 5 new formulas.Conclusion:In terms of treatingⅢtype chronic prostatitis,National Chinese medicine master Lin Tiandong adopts the principle of clearing heat and drying dampness,supplemented by inducing diuresis and relieving stranguria,purging heat and detoxification,promoting stagnation and dispersing blood stasis,etc.The drugs used are mostly cold,mild,warm,bitter,sweet,pungent,and bland,etc.