中西医治疗宫颈人乳头瘤病毒感染研究进展

Research Progress in the Treatment of Cervical Human Papilloma Virus Infection with Traditional Chinese and Western Medicine

中西医治疗宫颈人乳头瘤病毒感染的方法主要包括西药治疗、中药治疗、物理及手术治疗、联合治疗等,且联合治疗较单一治疗的临床疗效更为显著。但现有研究仍存在以下不足之处:(1)目前只有个别联合治疗方案研究表明了其显著的疗效,缺乏更多研究结果来证实;(2)中药内服联合外用的治疗药物较少,且治疗方案较单一,阴道纳药多使用现有中成药制剂,缺乏更多关于阴道纳药、宫颈涂药的药物研究;(3)许多中药方剂治疗HPV感染疗效确切,但未经现代药理学研究证实。今后,可着重从以下几方面进行研究:(1)对于只有个别研究证实其疗效的联合治疗方案,可采用随机对照的临床研究方法进行更多的研究证实;(2)进一步探索其他疗效确切的外用中药制剂及疗效更为显著、安全性更高的中药联合治疗方案,如中药汤剂内服联合中药洗剂阴道冲洗及中药膏剂宫颈涂药治疗,口服中药汤剂改善体质的同时,阴道给药直达病所,双管齐下提高疗效;(3)对于一些临床上确有其效,但尚未经过现代医学药理毒理研究证实的中药方剂,可以结合网络药理学研究,探索这些方剂中的药物是否确有抗宫颈HPV感染、抗宫颈癌的效果,以期为中药方剂治疗本病提供现代药理学依据。

The methods of traditional Chinese and Western medicine for treating cervical human papilloma virus(HPV)infection mainly include Western medicine treatment,TCM treatment,physical and surgical treatment,combined treatment,etc.The clinical efficacy of the combined therapy is more significant than that of a single treatment method.However,existing research still has the following shortcomings:(1)Currently,only a few studies have shown significant therapeutic effects in some combined therapy regimens,and there is a lack of broader research to confirm them;(2)The treatment drugs and treatment plan of the combination of internal and external use of Chinese medicinals are relatively simple.Vaginal drug delivery mostly uses existing traditional Chinese patent medicine preparations,and there is a lack of more drug research on vaginal drug delivery and cervical drug delivery;(3)At present,there are many TCM formulas that have proven effective in clinical treatment of HPV infection but have not been confirmed to have their effects through modern pharmacological research.In the future,research can focus on the following aspects:(1)For combined therapy regimens that have only been confirmed to be effective in a few studies,more randomized controlled clinical research methods can be used to confirm their efficacy;(2)In the future,it is necessary to further explore other effective topical Chinese medicine preparations and more significant and safer TCM combined treatment plans compared to single treatment methods.For example,the combination of traditional Chinese medicine decoction for oral administration,vaginal washing with Chinese medicinal lotion,and cervical application with Chinese medicinal oint-ment for treatment.Oral administration of Chinese medicinal decoction improves physical fitness while vaginal administration directly reaches the disease site,achieving a dual effect to improve efficacy;(3)For some TCM formulas that have been clinically effective but have not been confirmed by modern medical pharmacology and toxicology research,further network pharmacology research can be applied to explore whether the drugs in these formulas have anti-cervical HPV infection and anti-cervical cancer effects,in order to provide modern pharmacology basis for the treatment of cervical HPV infection with TCM formulas.