Notch信号通路调节肿瘤相关巨噬细胞分化影响NSCLC细胞侵袭性的研究进展

Research progress of Notch signaling pathway regulating tumor - associatedmacrophage differentiation and influencing invasion of NSCLC cells

非小细胞肺癌(non-small cell lung cancer, NSCLC)是临床常见的恶性肿瘤,癌细胞的侵袭和转移是导致NSCLC患者死亡的主要原因,肿瘤相关巨噬细胞(tumor-associated marcrophages, TAMs)与此密切相关。TAMs是肿瘤浸润免疫细胞的重要组成部分,在肿瘤微环境(tumor microenvironment, TME)中有向M2表型分化的倾向,具有促进肿瘤细胞增殖、侵袭及迁移的作用。TAMs的分化受多种细胞因子和信号通路的调节,Notch信号通路是其中之一。该文就Notch信号通路调节TAMs分化影响NSCLC细胞侵袭性的相关研究进行综述,为NSCLC的诊治提供有价值的资料。

Non-small cell lung cancer(NSCLC)is a common malignant tumor in clinical practice.The invasion and metastasis of cancer cells are the main causes of death in NSCLC patients,and tumor-associated macrophages(TAMs)are closely related to it.TAMs are important component of tumor-infiltrating immune cells and have a tendency to differentiate into M2 phenotype in the tumor microenvironment(TME),which can promote the proliferation,invasion and migration of tumor cells.The differentiation of TAMs is regulated by many cytokines and signaling pathways.Notch signaling pathway is one of them.In this paper,we reviewed the related studies on Notch signaling pathway regulating TAMs differentiation and influencing the invasion of NSCLC cells,so as to provide valuable data for the diagnosis and treatment of NSCLC.