羰基化反应在大宗化学品以及精细化学品合成中的应用

Application of Carbonylation in the Synthesis of Bulk and Fine Chemicals

简单的有机化合物如不饱和烃、卤代烃等与一氧化碳反应合成含羰基官能团化学品的羰基化反应因具有原子经济性、对环境友好及化学/区域选择性高等优点而备受关注. 综述了近几年通过发展新催化剂体系催化羰基化反应合成具有工业应用前景的大宗化学品和精细化学品的研究进展, 包括氢甲酰化反应合成醛, 氢酯化反应合成酯, 氢酰胺化反应合成酰胺, “氢甲酰化-氢化”串联反应合成醇, 以及合成酸酐、酮、酰卤等高附加值产品. 最后, 对羰基化反应在合成大宗化学品以及精细化学品中的发展前景以及存在难点进行展望, 以期发展更多类型的羰基化反应为其工业化应用提供参考.

The reaction between unsaturated/halogenated hydrocarbons and carbon monoxide to construct chemicals containing carbonyl modules has attracted much attention due to its advantages,such as atomic economy,environmental friendliness and high chemical/regional selectivity.The research progress in the synthesis of bulk and fine chemicals with industrial application prospects through the construction of new catalytic systems for carbonylation in recent years is summarized,including the synthesis of aldehydes through hydroformylation,esters through hydroesterification,amides through aminocarbonylation,alcohols through“hydroformylation hydrogenation”tandem reaction,as well as the synthesis of high value-added products such as acid anhydrides,ketones,and acyl halides.Finally,the development prospects and existing difficulties of carbonylation are discussed,hoping to provide reference for promoting the industrial application of carbonylation reactions.