镍催化1,6-烯炔与芳基卤化物的反式还原芳基化环化

Nickel-Catalyzed Reductive anti-Arylative Cyclization of 1,6-Enynes with Aryl Halides

发展了一种镍催化1,6-烯炔与芳基卤化物的反式还原芳基化环化反应. 该反应避免了化学计量有机金属试剂的使用, 而且条件温和、官能团兼容性好、底物范围广. 许多天然产物和生物活性化合物中广泛存在各种碳环和杂环骨架, 该方法为这些骨架的合成提供了一个高效的平台.

A nickel-catalyzed reductive trans-arylative cyclization of 1,6-enynes with aryl halides has been developed.This transformation avoids the use of stoichiometric organometallic reagents and features mild conditions,good functional group tolerance and broad substrate scope.This method serves as an efficient platform for the synthesis of various carbo-and heterocycles,which are abundant in many natural products and biologically active compounds.