昼夜节律基因在创面愈合中的作用机制研究进展

Research advances on the mechanism of circadian rhythm genes in wound healing

皮肤损伤后的愈合是多种细胞、细胞因子以及细胞外基质相互作用的动态过程,任何一个环节的异常都将影响创面愈合的速度和质量。昼夜节律是生物体内自发形成的周期性振荡循环,在维持内环境稳态和调控生理活动中发挥着重要作用。研究表明昼夜节律基因在创面愈合过程中扮演着关键角色。该综述总结了昼夜节律基因对创面愈合不同阶段的影响及其可能的作用机制,以期为创面愈合提供一个新的视角,并为制订更有效的难愈性创面的治疗策略提供理论依据。

The healing after skin injury is a dynamic process of the interaction of various cells,cytokines,and extracellular matrix,and the abnormality of any link will affect the speed and quality of wound healing.Circadian rhythm is a spontaneous periodic oscillation cycle in organisms,which plays an important role in maintaining homeostasis and regulating physiological activities.Studies have shown that circadian rhythm genes play a key role in wound healing.This review summarizes the effects of circadian rhythm genes on different stages of wound healing and its possible mechanism of action,in order to provide a new perspective for wound healing and provide theoretical basis for formulating more effective treatment strategies for refractory wounds.