寄生虫及其相关物治疗炎症性肠病转归进展

Advances in the treatment of inflammatory bowel disease with parasites and their agents

炎症性肠病(IBD)是一种病因尚未完全明确、以肠道症状为主的肠道疾病。该病迁延难愈,为国内外肠道疾病的疑难病,严重影响患者生存质量。近年研究发现,寄生虫及其相关物作用宿主后,可诱导一系列免疫应答,调节免疫微环境及改善肠道菌群,减轻炎症症状。本文就寄生虫及其相关物实验治疗IBD的最新研究进展进行综述,以期为治疗IBD的新型药物研发提供参考。

Inflammatory bowel disease(IBD) is a type of intestinal disease whose etiology has not been completely defined and is mainly characterized by intestinal symptoms. This disease is protracted and difficult to cure,making it a challenging medical condition both domestically and internationally, and seriously affects the life quality of the patients. Recently, it has been found that parasites and their related agents can regulate the immune microenvironment, improve intestinal flora and reduce inflammatory symptoms by inducing a series of immune responses after acting on the host. In this paper, the latest research advances in the experimental treatment of IBD with parasites and related agents are reviewed to provide a reference for developing new drugs for the treatment of IBD.