Na_(2)S_(2)O_(8)介导的咪唑并[1,2-α]吡啶与杂芳胺在无金属条件下的C—H胺化反应

Na_2S_2O_(8)Mediated C—H Amination of Imidazo[1,2-α]pyridines with Heteroaromatic Amines under Metal-Free Conditions

发展了一种高效实用的氨化咪唑[1,2-α]吡啶类化合物的方法.值得注意的是,该反应无需任何金属催化剂参与.在中等至高收率下,成功得到了带有多样取代基的产物.

A highly efficient and practical amination protocol for imidazo[1,2-α]pyridines using heteroaromatic amines was developed.Notably,the transformation proceeds without the need for any metal catalyst.Isolation of products bearing diverse substituents was achieved in moderate to high yields.