等离子体活化水用于微生物消杀的意义和现状

Significance and Current Status of Plasma-activated Water for Microbial Inactivation

等离子体活化水作为大气压冷等离子体的一种主要衍生形式,近年来成为等离子体生物医学领域的研究热点。等离子体活化水能够储存等离子体中的活性成分,具备与等离子体相近的生物效应,能高效杀菌;具有良好的均匀性和流动性,可通过擦拭、冲洗等多种方式应用于多种消毒场景,包括环境和物体表面的消毒、食品保鲜等;因其具有的低刺激性和良好的生物安全性,也可用于感染性疾病的治疗。基于等离子体活化水的这些特性和应用,近年来围绕着活化水的制备和性质、对微生物消杀效应及其机制、等离子体活化水制备装置的研发及应用发展等方面开展了大量研究工作,增加了对等离子体活化水化学和生物学机制的认识,为等离子体活化水的应用转化提供了科学依据。文中综述了等离子体活化水用于微生物消杀的基本原理、研究现状和发展方向,以期为同行学者、研究生和企业技术人员提供参考。

Plasma-activated water(PAW),as a main form of agents activated by cold atmospheric-pressure plasma,has become a research hotspot in the plasma field in recent years.PAW can store the reactive species in plasma,has similar biological effects with plasma,and can also effectively inactivate bacteria.PAW exhibits good uniformity and fluidity,and can be applied for a variety of disinfection scenarios in different ways,including disinfection of environment and object surface,food preservation,etc.Because of the low irritation and good biosafety,PAW can also be applied for the treat-ment of infectious diseases in vivo.Based on these characteristics and applications of PAW,a lot of studies have been performed in recent years around the preparation and properties of PAW,the inactivation effects on microorganisms and the underlying mechanisms,the development and application of PAW preparation devices,etc.These studies can not only increase the understanding of the interaction between the reactive species of plasma and water and the mechanism of re-active species in aqueous solutions and explanation of the chemical and biological mechanism of PAW but also expand the preparation and application of PAW and the preparation efficiency and biological effects of PAW,providing a scien-tific basis for the practical application of PAW.Therefore,this paper reviews the basic principles,research status,and development direction of plasma activated water for microbial abatement,so as to provide reference for peer scholars,postgraduate students and counterparts in enterprises.