基于数据挖掘探讨陈其华教授治疗慢性前列腺炎用药规律

Medication Rules of Professor Chen Qihua in Treating Chronic Prostatitis Based on Data Mining

目的:探讨陈其华教授治疗慢性前列腺炎用药规律。方法:收集整理陈其华教授门诊2019年6月-2021年10月194例慢性前列腺炎首诊处方,采用数据挖掘分析慢性前列腺炎的主要临床症状、药物频次及症状药物关联度。结果:纳入的194例慢性前列腺炎患者以中青年男性为主,其舌脉象以淡红舌,薄白苔,细脉出现最多;症状频次≥40次分别为尿频、口干、尿急、小腹痛、尿不尽、尿痛;共涉及112味中药,用药频次2515次,高频核心药物有30味,使用频次前5位的分别为甘草、山药、白术、没药、乳香;高频核心药物四气以平、温、寒为主;五味以苦、甘、辛为主;归经以肝、脾、肾为主;功效分类以活血化瘀药、补气药、清热药为主。聚类分析得到治疗上关系密切的药对13个。结论:陈其华教授认为慢性前列腺炎病位在精室,与肝肾关系密切,总以肾虚、气滞、湿热、血瘀为主,主张“祛邪不伤正,祛邪更扶正”的治疗思路,治疗时通补兼施、因地制宜,用药上善于“以静制动、动静结合”,在辨证基础上选择合适的药物。

Objective:To explore the medication rules of Professor Chen Qihua in the treatment of chronic prostatitis.Methods:194 first-diagnosed prescriptions of chronic prostatitis were collected from Professor Chen Qihua's outpatient clinic from June 2019 to October 2021.Data mining was used to analyze the main clinical symptoms,drug frequency and symptom-drug correlation of chronic prostatitis.Results:The included 194 patients with chronic prostatitis were mostly young and middle-aged men,and their tongue and pulse symptoms were light red tongue,thin white coating,and thin pulses the most.urinary incontinence,dysuria;a total of 112 traditional Chinese medicines were involved,and the frequency of use was 2 515.There were 30 high-frequency core medicines.Qi is mainly composed of flat,warm and cold;the five flavors are mainly bitter,sweet and acrid;the liver,spleen,and kidney are the main meridians;the functions are mainly classified as blood-activating and stasis-removing medicines,qi-tonifying medicines,and heat-clearing medicines.The cluster analysis obtained 13 drug pairs that were closely related in treatment.Conclusion:Professor Chen Qihua believes that chronic prostatitis is located in the sperm room,which is closely related to liver and kidney,and it is mainly characterized by kidney deficiency,qi stagnation,damp-heat and blood stasis.He advocates the treatment idea of “eliminating evil without hurting the healthy body,eliminating evil and strengthening the healthy body”.When treating it,he should apply both purgation and tonification,adapt to local conditions,be good at “static braking,dynamic and static combination”,and use drugs accurately on the basis of syndrome differentiation.