正念减压对辅助生殖助孕患者干预效果的Meta分析

Mindfulness-Based Stress Reduction for Patients Undergoing Assisted Reproductive Technology Treatment:A Meta-Analysis of Intervention Effect

目的:系统评价正念减压对辅殖助孕患者的干预效果。方法:检索中国知网、中国生物医学文献数据库、万方数据知识服务平台、维普、PubMed、The Cochrane Library、Embase、Web of Science数据库,收集建库至2023年12月发表的有关正念减压在辅助生殖助孕患者中应用的随机对照试验。由两名研究者对文献进行筛选、评价和资料提取,并评价纳入研究的偏倚风险。采用RevMan5.4和Stata17.0软件对纳入文献进行数据分析。结果:共纳入9项研究,1642例患者。Meta分析结果显示:与常规治疗相比,正念减压干预有助于改善辅助生殖助孕患者的心理状态,减轻压力知觉,提高生活质量。以抑郁自评量表(SDS)为评价标准[MD=-8.17,95%CI(-9.16,-7.17),P<0.01],以焦虑自评量表(SAS)为评价标准[MD=-8.71,95%CI(-10.24,-7.18),P<0.01],以压力知觉量表(CPSS)为评价标准[MD=-4.38,95%CI(-5.41,-3.35),P<0.01]。健康状况量表(SF-36量表)的4个评价维度:精神健康[MD=17.50,95%CI(15.67,19.33),P<0.01]、精力[MD=12.05,95%CI(10.18,13.92),P<0.01]、生理职能[MD=8.15,95%CI(6.51,9.79),P<0.01]、生理功能[MD=14.50,95%CI(12.65,16.35),P<0.01]。结论:现有证据表明,正念减压对辅助生殖助孕患者干预效果显著,但受本次纳入研究证据数量、质量限制,尚需开展更多有关辅助生殖助孕患者正念减压干预的高质量研究。

Objective:To systematically evaluate the effect of mindfulness-based stress reduction intervention on patients undergoing assisted reproductive technology treatment.Methods:By searching CNKI,China Biology Medicine database,Wanfang Data Knowledge Service Platform,VIP,PubMed,The Cochrane Library,Embase,Web of Science databases,the randomized controlled trials on mindfulness-based stress reduction in patients undergoing assisted reproductive technology treatment published up to December 2023 were collected.Two researchers independently screened the literature,assessed the quality,extracted data,and evaluated the risk of bias of the included studies.RevMan 5.4 and Stata17.0 software were used for Meta-analysis.Results:A total of 9 studies with 1642 patients were included.The results of Meta-analysis showed that compared with the control group,mindfulness-based stress reduction intervention was effective in improving the psychological state,reducing perceived stress,and enhancing the quality of life in patients undergoing assisted reproductive technology treatment.Statistically significant improvements were observed using the self-rating depres-sion scale(SDS)[MD=-8.17,95%CI(-9.16,-7.17),P<0.01],self-rating anxiety scal(SAS)[MD=-8.71,95%CI(-10.24,-7.18),P<0.01],Chinese perceived stress scale(CPSS)[MD=-4.38,95%CI(-5.41,-3.35),P<0.01].The four dimensions of the health status scale(SF-36 scale)also showed significant differences:mental health[MD=17.50,95%CI(15.67,19.33),P<0.01],vitality[MD=12.05,95%CI(10.18,13.92),P<0.01],role-physical function[MD=8.15,95%CI(6.51,9.79),P<0.01],physi-cal functioning[MD=14.50,95%CI(12.65,16.35),P<0.01].Conclusion:Existing evidence shows that mindfulness-based stress reduction has significant intervention effect on patients undergoing assisted reproductive technology treatment.However,due to the quan-tity and quality of the evidence included in this study,more high-quality studies on mindfulness-based stress reduction intervention in patients undergoing assisted reproductive technology treatment is needed.