苍附导痰汤对痰湿型多囊卵巢综合征患者卵泡发育的影响

Effect of Cangfu Daotan decoction on follicular development in patients with phlegm-dampness type PCOS

目的:观察苍附导痰汤对痰湿型多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者卵泡发育的影响,以期为痰湿型PCOS患者的治疗提供参考依据。方法:选择2021年1月至2021年12月收治的80例痰湿型PCOS患者为入选病例,随机分为对照组40例和试验组40例。试验组给予苍附导痰汤治疗6个月,对照组给予安慰剂,观察两组患者治疗前后痰湿证候积分、排卵率、脂肪因子(Apelin)和胰岛素抵抗指数(homeostasis model assessment-insulin resistance,HOMA-IR)水平,并分析Apelin和HOMA-IR相关性。结果:与对照组相比,试验组的平均年龄、不孕年限、体重指数等的差异无统计学意义(P>0.05)。与治疗前相比,对照组治疗后痰湿证候积分、排卵率、Apelin、HOMA-IR水平的差异无统计学意义(P>0.05);试验组治疗后痰湿证候积分降低(P<0.05),排卵率升高(P<0.05),Apelin、HOMA-IR水平均降低(P<0.05)。Pearson相关性分析发现,治疗后Apelin水平与HOMA-IR水平之间呈正相关(P<0.05)。结论:苍附导痰汤可有效改善痰湿型PCOS患者痰湿症状及胰岛素抵抗状况,降低血清Apelin水平,促进卵泡发育,提高排卵率。

Objective:To observe the effect of Cangfu Daotan decoction on follicular development in patients with phlegm-dampness type polycystic ovary syndrome(PCOS),hoping to provide reference for the treatment of PCOS patients with phlegm dampness.Methods:A total of 80 PCOS patients with phlegm dampness admitted in the Third People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2021 to December 2021 were selected and randomly divided into the control group(n=40)and the experimental group(n=40).The experimental group was treated with Cangfu Daotan decoction for 6 months,while the control group was given the placebo.The phlegm-dampness syndrome score,ovulation rate,adipose factor(Apelin),and insulin resistance index(HOMA-IR)of the two groups of patients were observed before and after treatment,and the correlation between Apelin and HOMA-IR was analyzed.Results:There was no statistically significant difference in the average age,infertility years,body mass index,etc.of the two groups(P>0.05).No statistically significant difference in the score of phlegm-dampness syndrome,ovulation rate,Apelin,and HOMA-IR levels was found in the control group before and after treatment(P>0.05).After treatment,the score of phlegm-dampness syndrome in the experimental group decreased(P<0.05),the ovulation rate increased(P<0.05),and the levels of Apelin and HOMA-IR decreased(P<0.05).Pearson correlation analysis results showed a positive correlation(P<0.05)between Apelin levels and HOMA-IR levels after treatment.Conclusion:Cangfu Daotan decocotion can effectively improve phlegm dampness symptoms and insulin resistance in patients with phlegm-dampness type PCOS,reduce serum Apelin levels,promote follicular development,and increase ovulation rate.