舒芬太尼联合罗哌卡因对产妇产程、产后抑郁及新生儿结局的影响

Effect of sufentanil combined with ropivacaine on labor process,postpartum depression and neonatal outcome

目的:探讨舒芬太尼配伍罗哌卡因在产妇及新生儿中的应用效果。方法:本研究采取前瞻性研究,以本院自然分娩的产妇150例作为研究对象,按照随机分组原则分为观察组和对照组,其中观察组80例,对照组70例。观察组孕产妇采取舒芬太尼0.5μg/ml以及0.075%罗哌卡因进行麻醉维持,对照组孕产妇仅采用0.15%罗哌卡因进行麻醉维持。比较两组患者的镇痛效果、产程、新生儿情况以及产后抑郁之间的差异。结果:观察组孕产妇镇痛后各个时间点的VAS评分低于对照组(P<0.05);观察组孕产妇的第一产程、第二产程低于对照组(P<0.05);两组新生儿的情况之间比较,差异均不存在统计学意义(P>0.05);产后42 d,观察组抑郁率显著低于对照组(P<0.05)。结论:在分娩镇痛中采用舒芬太尼配伍罗哌卡因治疗,孕产妇产程显著下降,对于新生儿的影响较小,可改善产后抑郁,安全性较高,建议临床推广。

Objective:To investigate the application effect of sufentanil combined with ropivacaine in parturients and newborns.Methods:This study adopted a prospective study included 150 women who gave birth naturally in our hospital as research subjects and divided them into observation and control groups according to the principle of random grouping,of which 80 were in the observation group and 70 were in the control group.The observation group received sufentanil(0.5 μg/ml)and ropivacaine(0.075%)for anesthesia maintenance,whereas the control group received 0.15% ropivacaine for anesthesia maintenance.The analgesic effect,labor process,neonatal condition,and postpartum depression were compared between the two groups.Results:The VAS score in the observation group was lower than that in the control group at each time point after analgesia(P<0.05).The first and second stages of labor in the observation group were lower than those in the control group(P<0.05).There were no statistically significant between the two groups(P>0.05).On postpartum day 42,the depression rate in the observation group was significantly lower than that in the control group(P<0.05).Conclusions:The use of sufentanil combined with ropivacaine in labor analgesia can significantly reduce the labor process of pregnant women,has little impact on newborns,and can improve postpartum depression with high safety,suggesting clinical promotion.