基于数据挖掘探讨芳香疗法预防流行性感冒用药规律

Explore the Compatibility Principles of Aromatherapy for the Preventionof Influenza Based on Data Mining

目的:通过数据挖掘探讨芳香疗法预防流行性感冒的组方规律。方法:通过检索中国学术期刊网络出版总库(CNKI)、中文科技期刊数据库(维普)、万方数据知识服务平台等数据库,按照纳入标准和排除标准筛选运用芳香疗法预防流行性感冒临床试验研究文献中的方药数据,运用软件“中医传承计算平台v3.0”分析收集到的香薰预防流行性感冒处方用药规律,得出新方。结果:搜集到相关临床试验研究文献64篇,纳入香薰预防流行性感冒方64首,共涉及中药107味,使用频次≥10的中药有10味,分别为苍术、艾叶、广藿香、冰片、薄荷、白芷、石菖蒲、山柰、丁香和肉桂,药物性味以温、辛最多见,归经以脾、胃、肺经为主,功效分类以解表类、化湿类、温里类为主,聚类分析得到新处方3个。结论:预防流感的香薰中药,多芳香辛温,归脾、胃、肺经,聚类分析得到的新方1、2以预防温热疫类的流行性感冒为主,新方3以预防寒疫类流行性感冒为主。

Objective:Exploring the Formulation Patterns for Preventing Influenza with Aromatherapy Through Data Mining.Methods:By searching databases such as the China National Knowledge Infrastructure(CNKI),the Chinese Science and Technology Periodical Database(VIP),and the Wanfang Data Knowledge Service Platform,we screened clinical trial studies on the prevention of influenza with aromatherapy according to inclusion and exclusion criteria.Data on the prescriptions used in these studies were analyzed with the software“Traditional Chinese Medicine Inheritance Support Platform v3.0”to identify patterns in the use of aromatherapy for preventing influenza,resulting in new formulations.Results:We collected 64 related clinical trial studies,including 64 aromatherapy prescriptions for preventing influenza,involving a total of 107 Chinese herbs.There were 10 herbs with a usage frequency of≥10 times,namely:Atractylodes(Cang Zhu),Mugwort Leaf(Ai Ye),Patchouli(Guang Huo Xiang),Borneol(Bing Pian),Mint(Bo He),Angelica Dahurica(Bai Zhi),Acorus Tatarinowii(Shi Chang Pu),Cluster Mallow Fruit(Shan Zhi),Clove(Ding Xiang),and Cinnamon(Rou Gui).The properties and flavors of these herbs were mostly warm and pungent,with most targeting the spleen,stomach,and lung meridians.The effects were categorized mainly as surface-relieving,dampness-dissipating,and interior-warming.Cluster analysis yielded three new prescriptions.Conclusion:The aromatherapy herbs used for influenza prevention were predominantly aromatic,pungent,and warm,affecting the spleen,stomach,and lung meridians.Cluster analysis revealed that new prescriptions 1 and 2 were primarily aimed at preventing epidemic influenza of the warm-heat type,while new prescription 3 was aimed at preventing epidemic influenza of the cold type.