基于网状Meta分析不同针刺频次治疗慢性荨麻疹疗效

Efficacy of Different Acupuncture Frequencies in the Treatment of Chronic Urticaria:Network Meta-Analysis

目的:运用网状Meta分析不同针刺频次治疗慢性荨麻疹(Chronic Urticaria,CU)的疗效。方法:检索中国知网(CNKI)、维普(VIP)、万方(WanFang)、中国生物医学文献服务系统(SinoMed)、PubMed、Embase、Cochrane Library及Web of Science数据库中不同针刺频次治疗慢性荨麻疹的随机对照试验(RCTs),检索时间为建库至2023年4月。两位研究者按照纳排标准独立提取文献信息,并使用Cochrane 5.3风险评估工具评估纳入文献的质量,用RevMan 5.4、Stata 15.1软件进行数据分析。结果:纳入13项RCTs,1130名患者。分析结果显示,在总有效率方面,每日针刺联合抗组胺药、隔日针刺联合抗组胺药及每日针刺,与单用抗组胺药相比,差异均具有统计学意义;隔日针刺与抗组胺药物相比,差异无统计学意义;无论是否联合药物,每日针刺和隔日针刺对治疗慢性荨麻疹疗效,差异无统计学意义。概率排序:隔日针刺+抗组胺药>每日针刺+抗组胺药>每日针刺>隔日针刺>抗组胺药治疗。结论:隔日针刺联合抗组胺药治疗慢性荨麻疹疗效可能最佳,但从卫生经济学及减少药物不良反应的角度考虑,隔日针刺可能成为较优选择。由于该研究的局限性,后续需要高质量的研究进一步探索与验证。

Objective:To evaluate the efficacy of acupuncture treatment with different frequencies on chronic urticaria(CU)by frequency network Meta-analysis.Methods:The randomized controlled trials(RCTs)on different acupuncture frequencies in the treatment of chronic urticaria were retrieved from CNKI,VIP,WanFang,SinoMed,PubMed,Embase,Cochrane Library,and Web of Science databases from the time of database establishment to April 2023.Two researchers independently extracted the literature information according to the inclusion and exclusion criteria.The Cochrane 5.3 risk assessment tool was utilized to evaluate the quality of included studies,and data analysis was performed using RevMan 5.4 and Stata 15.1 software.Results:13 RCTs involving 1130 patients were included.The network Meta-analysis results indicated that in terms of total effective rate,the differences between daily acupuncture combined with antihistamines,alternate-day acupuncture combined with antihistamines,and daily acupuncture,compared with antihistamines,were statistically significant;There was no significant difference between alternate-day acupuncture and antihistamine drugs;Whether or not combined with drugs,there was no significant difference in the effect of daily acupuncture and alternate-day acupuncture on the treatment of chronic urticaria.Probability ranking:alternate-day acupuncture combined with antihistamine>daily acupuncture combined with antihistamine>daily acupuncture>alternate-day acupuncture>antihistamine treatment.Conclusion:The efficacy of alternate-day acupuncture combined with antihistamines in the treatment of chronic urticaria may be the best,but from the perspective of health economics and reduction of adverse drug reactions,alternate-day acupuncture may be a better choice.Due to the limitations of this study,high-quality studies are needed for further exploration and validation.