卵巢癌患者组织及血清ADPN、CA-125、CRABP2表达与临床病理特征及预后的相关性

Correlation between the expression of ADPN,CA-125,CRABP2 in tissues and serum of ovarian cancer patients and their clinical pathological features and prognosis

目的研究卵巢癌(OC)患者组织及血清脂联素(ADPN)、糖类抗原125(CA-125)、细胞视黄酸结合蛋白2(CRABP2)表达与临床病理特征及预后的相关性。方法选取2018年1月至2020年11月于沧州市人民医院妇科行手术切除的OC患者(OC组)97例为研究对象,另取卵巢良性肿瘤患者(良性组)99例以及无卵巢相关疾病的健康女性(对照组)100例,根据随访3年的预后情况将患者分为生存组(n=67)和死亡组(n=30),分析各组患者卵巢组织及血清中ADPN、CA-125、CRABP2表达及其与临床病理特征的关系。用多因素Logistic回归分析OC患者死亡的影响因素;用Kaplan-Meier法对OC患者3年生存率进行分析。结果OC组卵巢组织中CA-125、CRABP2阳性表达高于良性组,ADPN阳性表达低于良性组(P<0.05);血清中CA-125、CRABP2表达高于良性组和对照组,ADPN表达低于良性组和对照组(P<0.05)。生存组ADPN水平高于死亡组,CA-125、CRABP2水平低于死亡组(P<0.05)。血清ADPN水平与FIGO分期、淋巴结转移、病理分期呈负相关,与淋巴结清扫呈正相关(P<0.05);血清CA-125、CRABP2水平与FIGO分期、淋巴结转移、病理分期呈正相关,与淋巴结清扫呈负相关(P<0.05)。Logistic回归分析表明ADPN、CA-125、CRABP2是OC患者死亡的独立影响因素(P<0.05)。ADPN阳性表达患者3年总生存率明显高于ADPN阴性表达患者,CA-125阳性表达患者3年总生存率明显低于CA-125阴性表达患者,CRABP2阳性表达患者3年总生存率低于CRABP2阴性表达患者(P<0.05)。结论OC患者组织及血清中ADPN水平较低,CA-125、CRABP2水平较高,与患者临床病理特征和预后相关。

Objective To investigate the correlation between the expression of adiponectin(ADPN),carbohydrate antigen 125(CA-125),and cellular retinoic acid-binding protein 2(CRABP2)in the tissues and serum of ovarian cancer(OC)patients and their clinical pathological features and prognosis.Methods A total of 97 OC patients(OC group)who underwent surgical resection in the Department of Gynecology of Cangzhou City People's Hospital from January 2018 to November 2020 were regarded as the study subjects,and another 99 patients with benign ovarian tumors(benign group)and 100 healthy women without ovarian related diseases(control group)were selected.According to the 3-year follow-up prognosis,patients were separated into survival group(n=67)and death group(n=30).The expression of ADPN,CA-125,and CRABP2 in ovarian tissue and serum of each group and their relationship with clinical pathological features were analyzed.Logistic regression was applied to analyze the influencing factors of mortality in OC patients.Kaplan-Meier method was applied to analyze the 3-year survival rate of OC patients.Results The positive expression of CA-125 and CRABP2 in the ovarian tissue of the OC group was higher than that of the benign group,while the positive expression of ADPN was lower than that of the benign group(P<0.05).The expression of CA-125 and CRABP2 in serum was higher than that in the benign group and control group,while the expression of ADPN was lower than that in the benign group and control group(P<0.05).The ADPN level in the survival group was higher than that in the death group,while the CA-125 and CRABP2 levels were lower than those in the death group(P<0.05).The serum ADPN level was negatively correlated with FIGO staging,lymph node metastasis,and pathological staging,and positively correlated with lymph node dissection(P<0.05).The levels of serum CA-125 and CRABP2 were positively correlated with FIGO staging,lymph node metastasis,and pathological staging,and negatively correlated with lymph node dissection(P<0.05).Logistic regression analysis showed that ADPN,CA-125,and CRABP2 were independent influencing factors for mortality in OC patients(P<0.05).The 3-year overall survival rate of ADPN positive expression patients was significantly higher than that of ADPN negative expression patients,and the 3-year overall survival rate of CA-125 positive expression patients was significantly lower than that of CA-125 negative expression patients.The 3-year overall survival rate of CRABP2 positive expression patients was lower than that of CRABP2 negative expression patients(P<0.05).Conclusion The levels of ADPN in the tissues and serum of OC patients are lower,while the levels of CA-125 and CRABP2 are higher,which are related to the clinical pathological features and prognosis of patients.