铁死亡相关机制在骨肉瘤中的应用进展

Progress of ferroptosis-related mechanisms in osteosarcoma

骨肉瘤是一种常见的原发性恶性骨肿瘤, 具有高度侵袭性和远端转移性, 预后较差。铁是一种人体必需的营养素, 具有电子交换能力, 是细胞活动的重要参与者, 其代谢异常与骨肉瘤的进展密切相关。有研究证明铁死亡可以调节骨肉瘤进展, 在骨肉瘤的治疗中发挥重要作用。探讨铁死亡的相关分子机制在骨肉瘤中的应用及药物干预现状, 可为骨肉瘤的治疗提供新的策略。

Osteosarcoma is a common primary malignant bone tumor with highly aggressive and distal metastasis and poor prognosis.Abnormal metabolism of iron,an essential nutrient with electron-exchange capacity and an important participant in cellular activities,is closely associated with the progression of osteosarcoma.Ferroptosis has been shown to regulate osteosarcoma progression and play an important role in the treatment of osteosarcoma.Exploring the application of relevant molecular mechanisms of ferroptosis in osteosarcoma and the current status of pharmacological intervention may provide new strategies for the treatment of osteosarcoma.