多裂黄檀中两个新的异黄酮类化合物

Two new isoflavones from Dalbergia rimosa Roxb.

研究多裂黄檀Dalbergia rimosa Roxb.根茎的化学成分。采用硅胶、MCI和Sephadex LH-20柱色谱以及半制备高效液相色谱等技术进行分离纯化,通过波谱数据鉴定化合物结构。从多裂黄檀根茎的乙酸乙酯部位中分离得到13个化合物,分别鉴定为多裂异黄酮A、B(1和2)、刺芒柄花素(3)、7,4′-二甲氧基异黄酮(4)、4′,6,7-trimethoxyisoflavone(5)、鹰嘴豆芽素A(6)、樱黄素(7)、7-O-methyltectorigenin(8)、3′-hydroxydaidzein(9)、orobol7,3′-dimethyl ether(10)、2′,7-dihydroxy-4′,5′-dimethoxyisoflavone(11)、pruinosanone E(12)、caviunin(13)。其中,化合物1和2为新化合物,化合物3~13为首次从该植物中分离得到。化合物9和11对DPPH自由基有显著清除作用。

Studies on chemical constituents in the rhizome of Dalbergia rimosa Roxb.The chemical constituents from the ethyl acetate part of D.rimosa were isolated and purified by silica gel,MCI gel,Sephadex LH-20 gel and semi-preparative HPLC,and the stuctures were identified by spectral method.Thirteen compounds were isolated from the ethyl acetate part of the rhizome of D.rimosa and identified as dalbergiaisoflavones A,B(1,2),formononetin(3),7,4′-dimethoxyisoflavone(4),4′,6,7-trimethoxyisoflavone(5),biochanin A(6),prunetin(7),7-O-methyltectorigenin(8),3′-hydroxydaidzein(9),orobol 7,3′-dimethyl ether(10),2′,7-dihydroxy-4′,5′-dimethoxyisoflavone(11),pruinosanone E(12),caviunin(13).Compounds 1 and 2 are new compounds,and compounds 3-13 were isolated from this plant for the first time.Compounds 9 and 11 had remarkable scavenging effect on DPPH free radicals.