预靶向在核医学临床应用中的研究进展

Research progress in pretargeting for clinical applications in nuclear medicine

预靶向是利用特定的亲和偶联系统, 使通过两步法依次向体内注射的特异性抗体和放射性核素发生自连接, 从而达到疾病显像和(或)治疗的目的的方法。预靶向核医学显像和治疗是基于抗体的传统放射免疫疗法的替代方法, 与传统放射免疫疗法相比具有许多优势。笔者将重点对目前已进入临床研究阶段的2种预靶向策略进行讨论, 阐述其目前在疾病显像和治疗方面的研究进展, 并比较不同方法之间的优缺点。

Pretargeting is a method that utilizes a specific affinity coupling system to selfattach specific antibodies and radionuclides that are sequentially injected into the body through a twostep process for disease imaging and/or treatment.Pretargeted nuclear medicine imaging and treatment is an alternative method to antibody-based conventional radioimmunotherapy,and has many advantages over conventional radioimmunotherapy.In this review,the authors will discuss two pretargeting strategies that have entered the clinical research stage,describe their current research progress in disease imaging and treatment,and compare the advantages and disadvantages of different approaches.