阿尔茨海默病治疗的研究进展

Advance in research on the treatment of Alzheimer's disease

阿尔茨海默病(AD)多发生于老年或老年前期,起病隐匿,以进行性认知功能障碍与行为损害为主要临床特征,是一种慢性、进行性中枢神经系统变性导致的皮质性痴呆。近年来,AD患病率在全球范围内显著上升,因此,探索AD的发病机制及靶向治疗策略对提高临床的诊疗效率与患者的生活质量具有重要价值。本文作者就AD的流行病特征与可能的发病机制、早期诊断及靶向治疗等展开综述,旨为临床工作及进一步研究提供参考。

Alzheimer's disease(AD)predominantly occurs in the elderly or pre-elderly,with an insidious onset characterized by progressive cognitive impairment and behavioral disturbances.It is a form of cortical dementia resulting from chronic,progressive central nervous system degeneration.In recent years,the prevalence of AD has significantly increased worldwide.Therefore,exploring the pathogenesis and targeted therapeutic strategies for AD is crucial for improving clinical diagnostic and treatment efficiency and enhancing patients'quality of life.The authors of this paper reviews the epidemiological characteristics,potential pathogenesis,early diagnosis,and targeted treatments of AD,aiming to provide references for clinical practice and further research.