蛋白磷酸化修饰调控卵母细胞成熟的研究进展

Research Progress on the Regulation of Protein Phosphorylation on Oocyte Maturation

哺乳动物卵母细胞减数分裂进程的有序进行是成功受精和随后胚胎发育的先决条件,也是有性生殖的基础。研究表明,许多蛋白质磷酸化修饰事件是调节减数分裂停滞或恢复、染色体分离以及纺锤体正确组装的关键。文章概述了磷酸化修饰在卵母细胞成熟过程中的作用,重点阐述了细胞周期蛋白依赖性激酶1(CDK1)、细胞外调节激酶(ERK)、极光激酶(AURKs)、蛋白激酶B(PKB)、单倍体生殖细胞特异性核蛋白激酶(Haspin)和蛋白磷酸酶1/2A(PP1/PP2A)在卵母细胞成熟过程中发挥的重要作用,以期为提高哺乳动物繁殖力和指导雌性动物不孕提供参考。

The orderly progression of meiosis in mammalian oocytes is a prerequisite for successful fertilization and subsequent embryonic development,as well as the foundation for sexual reproduction.Studies have shown that many protein phosphorylation modification events are important for regulating meiotic arrest or recovery,chromosome separation,and proper spindle assembly.The article provided an overview of the role of phosphorylation modification in oocyte maturation,with a focus on the important roles played by CDK1,ERK,AURKs,PKB,Haspin,and PP1/PP2A in oocyte maturation,in order to provide reference for improving mammalian reproductive capacity and guiding female animal infertility.