乙酰半胱氨酸溶液雾化吸入辅助治疗慢阻肺的效果

Effect of Acetylcysteine Solution Atomization Inhalation in the Treatment of Chronic Obstructive Pulmonary Disease

目的:探讨乙酰半胱氨酸溶液雾化吸入疗法应用于慢阻肺(COPD)患者的临床疗效及对患者免疫功能、肺功能、生活质量的影响。方法:选取2021年9月—2022年9月在本院确诊且接受治疗的COPD患者82例,按照随机数字表法分别建立常规治疗组及联合治疗组,每组41例。常规治疗组予以常规治疗,联合治疗组在常规治疗组基础上加用雾化吸入3 ml乙酰半胱氨酸溶液进行治疗。比较两组临床治疗效果、血清炎性因子指标、免疫功能指标、肺功能指标、生活质量评分、运动耐力情况。结果:联合治疗组临床治疗总有效率高于常规治疗组(P<0.05);联合治疗组TNF-α、IL-6、IL-8水平低于常规治疗组(P<0.05);联合治疗组FVC、FEV_(1)、FEV_(1)/FVC、PEF水平高于常规治疗组(P<0.05);联合治疗组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)值高于常规治疗组,CD8^(+)值低于常规治疗组(P<0.05);联合治疗组SGRQ评分低于常规治疗组、6MWT高于常规治疗组(P<0.05)。结论:乙酰半胱氨酸溶液雾化吸入疗法对提高COPD患者临床治疗总有效率、改善患者免疫功能、肺功能具有积极意义,值得临床应用。

Objective:To investigate the clinical efficacy of acetylcysteine solution atomization inhalation therapy in patients with chronic obstructive pulmonary disease(COPD)and its effect on immune function,lung function and quality of life.Methods:Eighty-two patients with COPD diagnosed and treated in our hospital from September 2021 to September 2022 were selected and randomly divided into conventional treatment group and combination treatment group,with 41 patients in each group.The control group was given routine therapy,and the combined therapy group was given aerosol inhalation of 3ml acetylcysteine solution on the basis of the control group.The clinical treatment effect,serum inflammatory factors,immune function,pulmonary function,quality of life score and exercise tolerance were compared between the two groups.Results:The total effective rate of clinical treatment in the combined treatment group was higher than that in the conventional treatment group(P<0.05).The levels of TNF-α,IL-6and IL-8 in the combined treatment group were lower than those in the conventional treatment group(P<0.05).The levels of FVC,FEV1,FEV1/FVC and PEF in the combined treatment group were higher than those in the conventional treatment group(P<0.05).The values of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the combined treatment group were higher than those in the conventional treatment group,and the value of CD8^(+)was lower than that in the conventional treatment group(P<0.05).The SGRQ score of the combined treatment group was lower than that of the conventional treatment group,and the 6MWT was higher than that of the conventional treatment group(P<0.05).Conclusion:Acetylcysteine solution atomization inhalation therapy has positive significance for improving the total effective rate of clinical treatment of COPD patients,improving the immune function and lung function of patients,and is worthy of clinical application.