基于我国虎杖苷研究的文献计量学分析

Bibliometric Analysis the Study of Polydatin in China

目的探讨虎杖苷领域研究现状和发展趋势,为未来临床及科研提供参考依据。方法系统检索中国知网收录的1993-2022年本领域文献,运用文献计量学软件对纳入数据进行可视化分析,基于发文趋势、学科主题分布、机构分布、作者合著性、刊源情况及关键词共现、聚类、突现情况,绘制网络可视化图谱。结果共纳入1013篇文献,发文量整体呈波动上升趋势,其中以中药学学科占比最多,形成以南方医科大学等院校的核心发文机构和以王兴勇、王振月和张翼为核心的热点特色团队。近年来出现较高频次及热点的关键词有细胞凋亡、氧化应激、炎症、细胞增殖、心肌细胞、动脉粥样硬化、NF-κB等。结论虎杖苷对包括心脑肾肝骨等多器官和组织具有保护作用,临床上主要用于心血管、呼吸、消化系统的疾病防治,基于细胞生物学、药理学和分子生物学等技术探索多靶点和多途径治疗疾病是未来的研究趋势。

Objective To explore the research status and development trend of polydatin,and to provide reference for future clinical and scientific research.Methods The literature in this field from 1993 to 2022 included in China National Knowledge Infrastructure(CNKI)was systematically searched,and the included data were visually analyzed by bibliometrics software.Based on the trend of publication,the distribution of subject topics,the distribution of institutions,the co-authorship of authors,the source of journals and the co-occurrence,clustering and burst of keywords,the network visualization map was drawn.Results A total of 1013 literatures were included,and the overall number of publications showed a fluctuating upward trend.Among them,the discipline of traditional Chinese medicine accounted for the largest proportion,forming the core publishing institutions of colleges and universities such as Southern Medical University and the hot characteristic team with WANG Xing-yong,WANG Zhen-yue and ZHANG Yi as the core.In recent years,the keywords with high frequency and hot spots were apoptosis,oxidative stress,inflammation,cell proliferation,myocardial cells,atherosclerosis,NF-κB and so on.Conclusion Polydatin has a protective effect on multiple organs and tissues including heart,brain,kidney,liver and bone.It is mainly used in the prevention and treatment of cardiovascular,respiratory and digestive diseases in clinic.Exploring the multi-target and multi-channel treatment of polydatin based on cell biology,pharmacology and molecular biology is the future research trend.