吸入用布地奈德混悬液联合吸入用异丙托溴铵溶液治疗小儿急性支气管炎的临床疗效及不良反应

Clinical Efficacy and Adverse Reactions of Budesonide Suspension for Inhalation Combined with Ipratropium Bromide Solution for Inhalation in the Treatment of Acute Bronchitis in Children

目的观察吸入用布地奈德混悬液联合吸入用异丙托溴铵溶液治疗小儿急性支气管炎的临床疗效及不良反应。方法选取2019年3月-2023年3月我院诊治的60例急性支气管炎小儿为研究对象,采用随机数字表法分为对照组(n=30)和观察组(n=30),对照组采用吸入用异丙托溴铵溶液治疗,观察组在对照组基础上联合应用吸入用布地奈德混悬液,比较两组临床疗效、临床症状(咳嗽、咳痰、气促)消失时间、肺功能指标[用力肺活量(FVC)、1 s用力呼气容积(FEV_(1))及呼吸峰流速(PEF)]、不良反应发生率。结果观察组治疗总有效率为93.33%,高于对照组的80.00%(P<0.05);观察组咳嗽、咳痰、气促消失时间均短于对照组(P<0.05);两组治疗后FVC、FEV_(1)、PEF均高于治疗前,且观察组高于对照组(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论吸入用布地奈德混悬液联合异丙托溴铵溶液治疗小儿急性支气管炎的效果确切,可改善肺功能,促进临床症状快速消失,且不增加不良反应发生率,具有良好的应用安全性和有效性。

Objective To observe the clinical efficacy and adverse reactions of budesonide suspension for inhalation combined with ipratropium bromide solution for inhalation in the treatment of acute bronchitis in children.Methods Sixty children with acute bronchitis diagnosed and treated in our hospital from March 2019 to March 2023 were selected as the research objects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with ipratropium bromide solution for inhalation,and the observation group was combined with budesonide suspension for inhalation on the basis of the control group.The clinical efficacy,disappearance time of clinical symptoms(cough,sputum,shortness of breath),pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in 1 second(FEV_(1))and peak expiratory flow(PEF)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 80.00%in the control group(P<0.05).The disappearance time of cough,sputum and shortness of breath in the observation group was shorter than that in the control group(P<0.05).After treatment,FVC,FEV_(1) and PEF in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Budesonide suspension for inhalation combined with ipratropium bromide solution is effective in the treatment of acute bronchitis in children,which can improve lung function,promote the rapid disappearance of clinical symptoms,and does not increase the incidence of adverse reactions.It has good application safety and effectiveness.