双苯并咪唑、噻唑衍生物的合成及其抑菌活性

Synthesis and Anti-Bacterial Activities of Bisbenzimidazoleand Bisbenzothiazole Derivatives

以2-氨基苯并咪唑和苯并噻唑分别与对苯二甲醛和邻苯二甲醛进行缩合反应,然后经硼氢化钠还原得到具有苯并咪唑和苯并噻唑功能基的4个新化合物,其结构通过1H NMR、13C NMR、MS、IR、元素分析以及单晶X-射线衍射等进行表征,采用96孔板倍比稀释法测定其抑菌活性,在甲醇及乙酸溶剂中测试其荧光发射光谱。结果表明,除2-氨基苯并咪唑与邻苯二甲醛的最终产物为2-异吲哚啉基苯并咪唑外,其余均可得到具有双苯并咪唑或苯并噻唑功能基的化合物,这些化合物在测试浓度范围内对测试菌种具有不同程度的抑菌活性,在不同溶剂中具有不同的荧光发射光谱。

By condensation reactions of 2-aminobenzimidazole and benzothiazole with p-benzaldehyde and o-benzaldehyde,respectively,four new compounds with functional groups of benzimidazole and benzothiazole were obtained by reduction of sodium borohydride.Its structure was characterized by'H NMR,3C NMR,MS,IR,elemental analysis,and single crystal X-ray diffraction,and its antibacterial activity was determined by 96 well plate dilution method,and their fluorescence emission spectra were tested in methanol and acetic acid solvents.The experimental results show that,except for the final product of 2-aminobenzimidazole and ortho benzaldehyde,which is 2-isoindolinebenzimidazole,all other compounds with functional groups of dibenzimidazole or benzothiazole can be obtained.These compounds have varying degrees of antibacterial activity against the tested strains within the test concentration range,and have different fluorescence emission spectra in different solvents.