间苯三酚联合维生素B6治疗妊娠剧吐的效果观察

Observation on the Effect of Phloroglucinol Combined with Vitamin B6 on Hyperemesis Gravidarum

目的分析间苯三酚联合维生素B6治疗妊娠剧吐的效果。方法通过随机数字表法将2020年5月至2022年5月菏泽市中医医院收治的60例妊娠剧吐孕妇分为对照组(30例)和观察组(30例),对照组给予维生素B6治疗,观察组给予维生素B6+间苯三酚治疗,记录两组的治疗相关时间、妊娠恶心呕吐专用量表(PUQE)评分、妊娠恶心呕吐生活质量量表(NVPQOL)和不良反应发生率。结果观察组呕吐改善、尿酮体转阴和住院时间与对照组相比较短(P<0.05)。与对照组比较,观察组治疗后PUQE、NVPQOL评分较低(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论间苯三酚与维生素B6联合应用具有较高的安全性,用药后可有效加强孕妇胃肠运动,改善进食欲望,并减轻呕吐症状,有利于促使孕妇康复,进而提升其生活质量。

Objective To analyze the effect of phloroglucinol combined with vitamin B6 on hyperemesis gravidarum.Methods Sixty pregnant women with hyperemesis gravidarum treated in Heze Traditional Chinese Medicine Hospital from May 2020 to May 2022 were randomly divided into control group(30 cases)and observation group(30 cases).The control group was given vitamin B6 treatment,and the observation group was given vitamin B6+phloroglucinol treatment.Treatment-related time,nausea and vomiting scale(PUQE)score,nausea and vomiting quality of life scale(NVPQOL)and incidence of adverse reactions.Results Vomiting was improved,urine ketone body turned negative and hospital stay in observation group were shorter than those in control group(P<0.05).Compared with the control group,the PUQE and NVPQOL scores of the observation group were lower after treatment(P<0.05),and there was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The combination of phloroglucinol and vitamin B6 has a high safety,and can effectively strengthen the gastrointestinal movement of pregnant women,improve the desire to eat,and reduce the symptoms of vomiting,which is conducive to promoting the recovery of pregnant women,and then improve their quality of life.