尼可地尔对冠心病介入治疗后心绞痛患者症状及近期预后的影响

Effect of Nicodil on Symptoms and Short-term Prognosis of Angina Pectoris Patients after Interventional Treatment of Coronary Hart Disease

目的探讨尼可地尔对冠心病介入治疗后心绞痛患者症状的干预效果以及对近期预后的影响。方法本次研究对象为在我院接受冠心病介入治疗的患者,共计80例,其就诊时间均在2021年3月至2023年3月。按照随机数字法将80例患者分别分为观察组(40例)和对照组(40例)。对照组患者采取介入术后常规用药方案,观察组则在此基础之上给予尼可地尔,对两组患者心绞痛症状的改善以及其近期预后情况进行对比和分析。结果经治疗后,观察组患者的LVEF水平相对于对照组较高(P<0.05),而LVEDD、RV和LVESD数值相对于对照组较低(P<0.05);经药物干预后,两组患者的发作频率和每次发作持续时间均有缩短,而且与对照组相比,观察组的发作频率更低,时间更短(P<0.05);术后6个月,两组患者的FMD和NO水平上升,ET-1水平下降,而且与对照组比较,观察组FMD和NO水平较高,ET-1水平较低(P<0.05)。术后6个月,观察组患者心绞痛再发作率、心绞痛Ⅲ级发生率以及重大不良心血管事件发生率低于对照组(P<0.05)。结论尼可地尔在冠心病介入治疗后心绞痛的治疗中获得了较好的干预效果,其可有效降低术后心绞痛的发作频率,可获得良好的近期预后。

Objective To investigate the intervention effect of nicodil on symptoms of angina pectoris patients after interventional treatment of coronary heart disease and the influence on short-term prognosis.Methods The subjects of this study were 80 patients who received interventional therapy for coronary heart disease in our hospital,all of whom visited our hospital from March 2021 to March 2023.According to random number method,80 patients were divided into observation group(40 cases)and control group(40 cases)respectively.The control group received conventional medication after interventional operation,while the observation group was given nicodil on the basis of this,and the improvement of angina pectoris symptoms and the short-term prognosis of the two groups were compared and analyzed.Results After treatment,LVEF level in observation group was higher than that in control group(P<0.05),while LVEDD,RV and LVESD values were lower than that in control group(P<0.05).After drug intervention,the frequency and duration of attacks in both groups were significantly shortened,moreover,compared with the control group,the frequency and duration of attacks in the observation group were still lower(P<0.05).Six months after surgery,FMD and NO levels increased and ET-1 levels decreased in two groups,moreover,compared with the control group,FMD and NO levels were higher and ET-1 levels were lower in observation group(P<0.05).Six months after operation,the recurrence rate of angina pectoris,the incidence of gradeⅢangina pectoris and the incidence of major adverse cardiovascular events in the observation group were lower than those in the control group(P<0.05).Conclusions Nicodil has a good intervention effect in the treatment of angina pectoris after interventional treatment of coronary heart disease,which can effectively reduce the frequency of postoperative angina pectoris,and can obtain a good short-term prognosis.