基于数据挖掘中药复方专利治疗流行性感冒的用药规律

Data mining based on the dosage pattern of Chinese herbal compound patents for the treatment of influenza

目的探索中国知网专利数据库中治疗流行性感冒的中药复方专利用药规律。方法检索自建库来至2024年3月25日中国知网专利数据库收录的治疗流行性感冒的中药复方,利用Microsoft Excel 2019软件分析符合筛选标准的复方中药的使用频次、性味归经等;运用SPSS Modeler 18.0软件Apriori算法对高频药物进行关联规则分析;运用SPSS 25.0软件对高频药物进行因子分析、聚类分析,筛选出核心药对和药物组合。结果共纳入中药复方451首,涉及685味中药,总用药频率4469次。使用频次最高的中药依次为金银花、炙甘草、连翘、黄芩、板蓝根、薄荷等;药性以寒为主,药味以苦为主,归经多归肺经;核心药物组合有金银花-连翘-炙甘草、连翘-牛蒡子-金银花等,得到了治疗流行性感冒的核心药对及常见药物组合。结论治疗流行性感冒的中药复方多用苦寒之品,治则以清热解毒为主,兼顾疏散风热、解表散寒、化湿醒脾、益气固表等治法,核心药对及药物组合的挖掘为更好地治疗流行性感冒及新药的研发提供了更广阔的思路。

Objective To explore the medication pattern of Chinese herbal compound patents for the treatment of influenza in the patent database of CNKI.Methods The Chinese herbal compound for treating influenza included in the patent database of CNKI from the inception to March 25,2024 were searched,and the frequency of use and the properties,taste and attributive meridians of Chinese herbal compound that conformed to the screening standard were analyzed by Microsoft Office Excel 2019 software.The Apriori algorithm of IBM SPSS Modeler 18.0 was used to analyze the association rules of the high frequency medicines.The factor analysis and cluster analysis of IBM SPSS Statistics 25.0 was applied to screen the core pairs and combinations of medicines.The drugs were analyzed by association rules.The high-frequency drugs were analyzed by factor analysis and cluster analysis using IBM SPSS Statistics 25.0,and the core pairs and drug combinations were screened out.Results A total of 451 Chinese herbal compound patents were included,involving 685 TCM flavors,with a total medication frequency of 4469 times.The most frequently used Chinese medicines were,in order,honeysuckle,roasted licorice,forsythia,scutellaria baicalensis,panax quinquefolium,mint,etc.The medicinal properties were mainly cold,the medicinal taste was mainly bitter,and the attributive meridians were mostly attributed to the lung meridian.The core drug combinations include honeysuckle-forsythia-baked licorice,forsythia-burdock-honeysuckle,etc.The core drug pairs and common drug combinations for the treatment of influenza were obtained.Conclusion Chinese herbal compound patents in the treatment of influenza mostly uses bitter and cold products,and the main treatment principle is to clear heat and detoxify toxins,taking into account the treatments of dispersing wind-heat,relieving epidemiological cold,transforming dampness and awakening the spleen,and benefiting qi to consolidate the epidemiology,etc.The excavation of the core pairs of medicines and combinations of medicines has provided a wider range of ideas for a better treatment of influenza and for the research and development of new medicines.