肠-肝互作在感染性肠/肝损伤中的作用及机制

Role and mechanism of intestinal-liver interaction in infectious intestinal/liver injury

感染是目前临床上常见的医学问题,不同的病原体会导致不同的感染,而严重的感染最终会引发脓毒症,导致全身多器官衰竭,增加患者的病死率。因此,研究严重感染的发生发展对提高患者的存活率至关重要。越来越多的研究揭示了肝脏与肠道的紧密联系在感染性疾病中发挥的重要作用。肠道机械屏障、生物屏障功能的维持及肠道菌群代谢物的调节可减轻感染性肝损伤。胆汁酸是肝脏的重要代谢物,其既可抑制某些感染性肠损伤的进程,也对某些病原体引起的肠道损伤有促进作用。本文对肠-肝轴在感染中的作用机制进行综述,为临床感染的治疗寻找新的靶点。

Infection is a common medical problem at present.Different pathogens can lead to different infections.Severe infections can ultimately lead to sepsis,resulting in multiple organ dysfunction and the high mortality of patients.Therefore,studying the occurrence and development of severe infections is essential to improve the survival rate of patients.More and more studies have revealed the important role of connection between intestine and liver in infectious diseases.The maintenance of intestinal mechanical barrier and biological barrier function and the regulation of intestinal flora metabolites can reduce infectious liver injury.Bile acids are important metabolites in the liver,which can inhibit the progression of certain infectious intestinal injuries and promote intestinal damage caused by certain pathogens.In this article,the mechanism of action of the intestinal-liver axis in infection was reviewed to find a new target for the treatment of clinical infection.