肠道环境紊乱对脓毒症相关肝损伤发生发展的机制研究进展

Research progress in the mechanism of intestinal environmental disturbance on the occurrence and development of sepsis-associated liver injury

脓毒症相关肝损伤(SALI)是脓毒症常见的并发症,其病理特点是脓毒症诱导的全身免疫紊乱对肝脏产生损伤。目前SALI尚无有效的治疗手段,这与其复杂的病理生理机制有关。近年来,脓毒症后肠道环境紊乱被认为是SALI的重要因素,但目前上述过程的具体分子机制仍不清楚。本文就肠道环境紊乱与SALI发生发展的病理学联系和分子机制的研究进展进行综述,旨在分析SALI潜在的研究方向,寻求治疗SALI潜在的治疗靶点。

Sepsis-associated liver injury(SALI)is a common complication of sepsis,which is characterized by systemic immune disorders induced by sepsis leading to liver damage.Currently,there are no effective treatments for SALI,which is related to its complex pathophysiological mechanisms.In recent years,the disorder of intestinal environment after sepsis has been considered as an important factor for SALI,but the specific molecular mechanism of the above process is still unclear.This article will review the pathological role and molecular mechanisms between intestinal environmental disturbance and SALI,aiming to analyze the potential research direction of SALI and identify potential therapeutic targets for its treatment.