基于数据挖掘技术探析针灸治疗肿瘤相关性失眠的选穴规律

Rules of acupoint selection in treatment of cancer-related insomnia with acupuncture and moxibustion based on data mining technology

目的:运用数据挖掘技术分析针灸治疗肿瘤相关性失眠的选穴规律。方法:检索中国知网、万方、维普、PubMed等数据库从建库至2024年1月5日针灸治疗肿瘤相关性失眠的相关文献,建立针灸治疗肿瘤相关性失眠的处方数据库,对使用频次、归经、分布等进行描述性分析,运用SPSS Modeler18.0 Apriori算法对处方进行关联规则分析,Cytoscape3.9.1软件绘制复杂网络图,SPSS26.0软件对高频腧穴进行聚类分析。结果:纳入文献41篇,提取针灸处方67条,涉及腧穴89个,总频次447次;腧穴使用频次排名前4位的是百会、三阴交、神门、神庭;所选经脉主要是督脉、脾经、膀胱经、任脉、心经、胃经等;选穴多集中在头项部和上、下肢部;特定穴中使用频次较高的为五输穴、交会穴、原穴;腧穴配伍中,神庭-三阴交-神门-百会四穴关联最强;前12位高频腧穴可分为3个有效聚类群。结论:针灸治疗肿瘤相关性失眠以扶正固本、兼以祛邪、燮理阴阳、通督调神、宁心安神为治疗原则,核心穴组为神庭-三阴交-神门-百会,还可加用足三里、印堂以增强治疗效果。

Objective To analyze the rules of acupoint selection in treatment of cancer-related insomnia with acupuncture and moxibustion by data mining technology.Methods The articles of cancer-related insomnia treated with acupuncture and moxibustion were searched from CNKI,Wanfang,VIP,SinoMed,PubMed,WOS,Cochrane,and Embase databases,from the inception of each database to January 5,2024.The prescription database of acupuncture and moxibustion for cancer-related insomnia was established.The descriptive analysis was conducted on the use frequency,meridian tropism and distribution of acupoints.Using SPSS Modeler 18.0 Apriori algorithm,the association rules of acupoint prescriptions were analyzed.With Cytoscape3.9.1 software used,the complex network diagram was plotted,and the cluster analysis of high-frequency acupoints was performed by SPSS26.0 software.Results Forty-one articles were included,and 67 prescriptions were extracted with 89 acupoints involved,and the total use frequency was 447 times.The top 4 acupoints of the high use frequency were Baihui(GV20),Sanyinjiao(SP6),Shenmen(HT7)and Shenting(GV24).The included meridians were the governor vessel,the spleen meridian,the bladder meridian,the conception vessel,the heart meridian and the stomach meridian.The selected acupoints were mostly distributed on the head,the neck and and the upper and lower limbs.The special acupoints of the high use frequency included the five-Shu points,the crossing points and yuan-primordial points.Regarding acupoint combination,GV24,SP6,HT7,and GV20 were highly correlated.The three effective clusters were categorized among the top 12 acupoints of the high use frequency.Conclusion In treatment of cancer-related insomnia with acupuncture and moxibustion,the principle focuses on supporting the healthy qi,eliminating pathogens,regulating yin and yang,promoting the circulation of the governor vessel for regulating the spirit,and tranquilizing the mind.The core acupoint prescription may includes GV24,SP6,HT7 and GV20;combined with Zusanli(ST36)and Yintang(GV4+)to enhance the therapeutic effect.