自黏附、近红外光响应水凝胶的制备及药物释放性能研究

Preparation and Drug Release Properties of Self-Adhesive,NIR-Responsive Hydrogels

水凝胶是一种亲水的三维网络结构,具有良好的生物相容性,可为细胞的迁移生长提供良好的支撑结构,常被用为细胞或药物的载体。然而,传统水凝胶缺乏对外界刺激的响应行为,难以实现在时间和空间上管理药物的释放。本文首先制备聚多巴胺-聚吡咯(PDA-PPy)纳米粒子,将其嵌入聚丙烯酰胺/聚(异丙基丙烯酰胺-co-丙烯酸)(PAM/P(NIPAm-co-AAc))水凝胶网络中,制备了具有近红外光响应的黏附水凝胶,并对其拉伸性能、黏附性、近红外光响应药物可控释放性能进行了讨论。结果表明:(1)当PDA-PPy-PAM在水凝胶中的含量增加时,水凝胶的延伸比率呈现先增加(从3倍提高到5倍)后减小的趋势,水凝胶的断裂应力呈现逐渐下降的趋势(从60kPa减小到30kPa);(2)所制备的水凝胶对玻璃、塑料和人体皮肤等物体表面具有良好的黏附效果;(3)水凝胶的NIR光热转换率随PDA-PPy纳米粒子含量增加而提高,当纳米粒子含量为1.8(wt)%时,水凝胶在NIR下辐射10min后,温度可达到45℃左右;(4)载有四环素的水凝胶在NIR辐射下药物释放量逐渐提高,120min后达到65%左右的释放率,抗菌效率可达近100%,而未被NIR辐射的水凝胶药物释放量只有5%。

Hydrogel is a kind of hydrophilic three-dimensional network structure,which has good biocompatibility and can provide a good support structure for cell migration and growth,and is often used as a carrier of cells or drugs.However,traditional hydrogels have the limit in responding to external stimuli,which make them difficult to manage the release of drugs in time and space.In this paper,by preparing PDA-PPy nanoparticles and embedding them into PAM/P(NIPAm-co-AAc)hydrogel network,adhesive hydrogels with NIR light response were prepared,and their tensile properties,adhesion properties and NIR drug controllable release properties were discussed.The results showed as follows:1)when the content of PDA-PPy-PAM in the hydrogel increased,the elongation ratio of the hydrogel increased first(from 3 to 5 times)and then decreased,while the fracture stress of the hydrogel decreased gradually from 60 kPa to 30 kPa.2)The prepared hydrogel can form a good adhesion effect on the surface of glass,plastics and human skin.3)The NIR photothermal conversion rate of hydrogel is affected by the nanometer content of PDA-PPy,and increases with the increase of nanoparticle content.When the content of nanoparticles is 1.8(wt)%,the temperature of hydrogel can reach about 45℃after 10 min irradiation under NIR.4)Under NIR radiation,the drug release of the hydrogel containing tetracycline gradually increased,after 120 min,the drug release reached 65%,and the antibacterial efficiency reached about 100%,while the drug release of the hydrogel not irradiated by NIR was only 5%.