镁补充改善糖尿病患者血清胰岛素水平的Meta分析

Meta-analysis of the Efficacy of Magnesium Supplement for Serum Insulin Levels in Diabetes Patients

系统评价口服镁补充改善糖尿病患者血清胰岛素水平的效果。采用计算机检索PubMed、EBSCO、The Cochrane Library、CNKI、Web of Science数据库,搜集口服镁补充改善糖尿病患者血清胰岛素水平的相关研究,独立筛查文献、提取资料并评价纳入研究的偏倚风险后采用R studio软件进行Meta分析。亚组分析结果显示,口服镁补充在镁缺乏糖尿病患者中[SMD=-0.29,95%CI(-1.07,0.48),P>0.01]、4~6周补充周期[SMD=-0.74(-1.69,0.20),P>0.01]、250~300 mg/d剂量[SMD=-63(-1.25,0),P<0.01]改善血清胰岛素水平效果更佳,说明口服镁补充对于改善糖尿病患者血清胰岛素水平具有良好的效果。

The effect of oral magnesium supplementation on serum insulin level in diabetic patients was systematically evaluated.Databases,including PubMed,EBSCO,The Cochrane Library,CNKI and Web of Science,were searched to investigate the effect of oral magnesium supplementation on serum insulin level in diabetic patients.Papers were independently screened,data were extracted,and the risk of bias of included studies were assessed.Then Meta-analysis was performed with R studio software.The results of subgroups presented that,the effect of oral magnesium supplement is more obvious in magnesium-deficient patients[SMD=-0.29,95%CI(-1.07,0.48),P>0.01],4~6 week duration time[SMD=-0.74(-1.69,0.20),P>0.01],250~300 mg dosage[SMD=-63(-1.25,0),P<0.01].The current evidence shows that,compared with control group,the oral magnesium supplement for diabetes patients can reduce serum insulin levels.