孤独症谱系障碍儿童的听性脑干反应特点

Characteristics of auditory brainstem responses in children with autism spectrum disorders

目的探究孤独症谱系障碍(ASD)儿童的听性脑干反应临床特征。方法回顾性选取我院39例ASD患儿为研究对象(ASD组),另选择同期健康儿童39例作为对照组,均进行听性脑干反应(ABR)检查,对比两组的ABR结果。结果两组儿童的性别对比无明显差异(P>0.05);ASD组左耳ABR的Ⅰ、Ⅲ、Ⅴ波潜伏期及Ⅰ~Ⅲ波间期均较对照组延长(P<0.05),Ⅲ~Ⅴ波间期、Ⅰ~Ⅴ波间期较对照组缩短(P<0.05);ASD组右耳ABRⅠ、Ⅲ波潜伏期均较对照组延长(P<0.05),Ⅲ~Ⅴ波间期、Ⅰ~Ⅴ波间期较对照组缩短(P<0.05),Ⅰ~Ⅲ波间期较对照组延长(P<0.05),而两组V波潜伏期对比无明显差异(P<0.05)。结论ASD患儿与健康儿童的ABR潜伏期和波间期均存在差异,提示ASD患儿具有听觉病理功能障碍,这对ASD患儿语言能力障碍的诊疗具有一定的临床意义。

Objective To explore the clinical features of auditory brainstem response in children with autism spectrum disorder(ASD).Methods 39 children with ASD in our hospital were retrospectively selected as the study objects as the ASD group,and 39 healthy children in the same period were selected as the control group.All of them were examined by auditory brainstem response(ABR)and the ABR results of the two groups were compared.Results There was no significant difference in gender between the two groups(P>0.05).The latency of left ear ABR waveⅠ,ⅢandⅤand the interval ofⅠ~Ⅲwave in ASD group were longer than those in control group(P<0.05),and the interval ofⅢ~Ⅴwave andⅠ~Ⅴwave in ASD group were shorter than that in control group(P<0.05).The latency of ABR waveⅠandⅢin the right ear in ASD group were longer than that in the control group(P<0.05),the interval ofⅢ~Ⅴwave andⅠ~Ⅴwave were shorter than that in the control group(P<0.05),and the interval ofⅠ~Ⅲwave was longer than that in the control group(P<0.05),but there was no significant difference in the latency of V wave between the two groups(P<0.05).Conclusion The study shows that the ABR latency and wave interval are different between children with ASD and healthy children,which indicates that children with ASD have auditory pathological dysfunction,which has certain clinical significance for the diagnosis of language impairment in children with ASD.