动脉型肺动脉高压治疗研究进展

Advances in Treatment of Pulmonary Arterial Hypertension

动脉型肺动脉高压(PAH)是一种慢性进展性心肺疾病,其主要病理改变是血管收缩和肺动脉增生性重构以及右心室肥厚引起肺动脉压力持续升高。深入探究PAH发病机制可以发现,其相关途径有血管增生、血管壁重构、氧化应激、炎症反应与基因调控等。虽然近年来PAH在治疗方面取得很大进展,但其死亡率仍然很高,当前临床治疗方法并未有效改善预后,该病对患者身体、社会、工作和情感等方面产生了很大影响。本文将对PAH治疗方面最新研究进行综述,以期为PAH临床治疗提供新的线索。

Pulmonary Arterial Hypertension(PAH)is a chronic progressive cardiopulmonary disease.The main pathological changes are vasoconstriction and pulmonary artery proliferative remodeling and right ventricular hypertrophy.Further exploration of the pathogenesis of PAH can reveal that its related pathways include vascular proliferation,vascular wall remodeling,oxidative stress,inflammatory response and gene regulation.Although great progress has been made in the treatment of PAH in recent years,the mortality rate is still high,current clinical treatments have not effectively improved the prognosis,and the disease has great impact on the physical,social,work and emotional aspects of patients.This article will review the latest research on the treatment of PAH,aiming to provide new clues for the clinical treatment of PAH.