维生素B_(6)、双歧杆菌三联活菌及猴头菌提取物对感染患儿静脉滴注红霉素胃肠道不良反应情况的影响

Effects of Vitamin B_(6),Bifidobacterium Trivialis and Hericium Extract on Gastrointestinal Adverse Reactions of Intravenous Infusion of Erythromycin in Infected Children

目的:对比维生素B_(6)、双歧杆菌三联活菌及猴头菌提取物对感染患儿静脉滴注红霉素胃肠道反应情况的影响。方法:选取2023年11月—2024年2月于潍坊医学院附属医院进行红霉素静脉滴注治疗的感染疾病患儿200例为研究对象,以随机数字表法分为对照组、维生素B_(6)组、双歧杆菌组及猴头菌组,各50例。在红霉素静脉滴注治疗的基础上,对照组不采取其他药物干预,维生素B_(6)组予以维生素B_(6)静脉滴注,双歧杆菌组予以口服双歧杆菌三联活菌,猴头菌组予以口服猴头菌提取物颗粒。比较四组患儿胃肠道不良反应发生率及胃肠功能分级评定表(GSRS)评分。结果:对照组与双歧杆菌组胃肠道不良反应发生率比较,差异无统计学意义(P>0.05);维生素B_(6)组、猴头菌组胃肠道不良反应发生率低于对照组及双歧杆菌组,差异有统计学意义(P<0.05)。对照组与双歧杆菌组胃肠道不良反应患儿GSRS评分比较,差异无统计学意义(P>0.05);维生素B_(6)组、猴头菌组胃肠道不良反应患儿GSRS评分低于对照组及双歧杆菌组,差异有统计学意义(P<0.05)。结论:维生素B_(6)、猴头菌提取物可控制感染患儿的红霉素静脉滴注胃肠道不良反应发生风险,临床可根据患儿实际情况选择药物以减少不良反应。

Objective:To compare the effects of vitamin B_(6),bifidobacterium and hericium extract on the gastrointestinal reaction of infected children receiving intravenous infusion of erythromycin.Methods:A total of two hundred children with infectious diseases who were treated with erythromycin intravenous infusion in the Affiliated Hospital of Weifang Medical College from November 2023 to February 2024 were selected as the study objects.By random number table method,they were divided into control group,vitamin B_(6)group,bifidobacterium group and hericium group,fifty cases each.On the basis of erythromycin intravenous infusion treatment,the control group did not take other drug intervention,vitamin B_(6)group was given intravenous infusion of vitamin B_(6),the bifidobacterium group was given oral bifidobacterium triplex live bacteria,and the hericium group was given oral hericium extract particles.The incidence of gastrointestinal adverse reactions and the score of Gastrointestinal Function Rating Scale(GSRS)were compared among the four groups.Results:There was no significant difference in the incidence of gastrointestinal adverse reactions between control group and bifidobacterium group(P>0.05);the incidence of gastrointestinal adverse reactions in vitamin B_(6)group and hericium group was lower than that in control group and bifidobacterium group,and the difference was statistically significant(P<0.05).There was no significant difference in GSRS scores between control group and bifidobacterium group(P>0.05);the GSRS scores of children with gastrointestinal adverse reactions in vitamin B_(6)group and hericium group were lower than those in control group and bifidobacterium group,and the difference was statistically significant(P<0.05).Conclusion:Vitamin B_(6)and hericium extract can control the risk of gastrointestinal adverse reactions of erythromycin intravenous infusion in infected children,and drugs can be selected according to the actual situation of children in clinical practice to reduce adverse reactions.